Curcumin: A review of its’ efficacy in the management of psoriasis

Abstract

Psoriasis is a long-term chronic inflammatory, autoimmune and reoccurring skin condition. About 2% to 5% of the world's population is impacted by psoriasis. People affected by psoriasis are more prone to develop other health conditions including psoriatic arthritis, anxiety, depression and cardiovascular disorders. Long-term use of several synthetic medications used for their management have been showing typical severe side effects. Curcumin, a natural compound generated from the golden spice (Curcuma longa) has been recommended as a potential alternative for the management of psoriasis. Curcumin works at molecular level by binding with the various inflammatory receptors that play key role in the initiation of psoriasis. The aim of this review is to report the use and discuss the mechanism of action of curcumin in the management of psoriasis, and mutually to overcome the side effects shown by the synthetic medications. Qualitative literature review Pub Med, Scopus, Web of Science, Google Scholar, Google Books, Science Direct meet the inclusion criteria. As a traditional herb curcumin appears as a beneficiary medicament because of its anti-oxidant, anti-inflammatory and immune-modulating activities proposing minimal side effects. Thereby ensuring its defensive mechanism towards psoriasis.