Fetuína-A plasmática en pacientes con preeclampsia y gestantes normotensas sanas

Perinatologia y Reproduccion Humana Pub Date : 2017-09-01 DOI:10.1016/j.rprh.2017.10.014

E. Reyna-Villasmil, J. Mejia-Montilla, N. Reyna-Villasmil, D. Torres-Cepeda, J. Santos-Bolívar

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引用次数: 0

Abstract

Objective

To compare plasma fetuin-A concentrations in patients with preeclampsia and healthy normotensive pregnant women.

Materials and method

A total of 100 patients were selected. Fifty patients with preeclampsia were selected as cases (Group A), and a control group selected with the same age and body mass index as the study group that consisted of 50 healthy normotensive pregnant women (Group B). Blood samples were collected from all patients before labour, and immediately after diagnosis in Group B to determine plasma fetuin-A concentrations.

Results

There was a statistically significant difference in plasma fetuin-A concentrations between patients in group A (279.1 ± 29.1 pg/ml) and patients in group B (328.1 ± 37.2; p<.001). There was no significant correlation with values of systolic and diastolic blood pressure (p= ns). Significant correlations were found between fetuin-A and aspartate transaminases (p<.05). A cut-off value of 300 pg/ml had a value under the curve of 0.86, sensitivity of 79.3%, specificity of 70.7%, a positive predictive value of 65.7%, and a negative predictive value of 82.6%.

Conclusion

Patients with preeclampsia had significantly higher plasma concentrations of fetuin-A when compared with healthy normotensive pregnant women.

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目的比较子痫前期孕妇与正常妊娠孕妇血浆中胎儿素a的含量。材料与方法共选取100例患者。50例先兆子痫患者作为病例(A组)，50例健康、体重指数正常的孕妇作为对照组(B组)。B组在分娩前和诊断后立即采血，测定血浆胎儿素A浓度。结果a组患者血浆胎儿素a浓度(279.1±29.1 pg/ml)与B组患者(328.1±37.2 pg/ml)差异有统计学意义;术;措施)。与收缩压和舒张压值无显著相关性(p= ns)。胎儿素a与天冬氨酸转氨酶之间存在显著相关性(p < 0.05)。截断值为300 pg/ml，曲线下值为0.86，敏感性为79.3%，特异性为70.7%，阳性预测值为65.7%，阴性预测值为82.6%。结论子痫前期患者血浆中胎儿素a浓度明显高于正常妊娠孕妇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Perinatologia y Reproduccion Humana

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Perinatología y Reproducción Humana is the official journal of the Instituto Nacional de Perinatología, Mexico. It is aimed at physicians of the area of perinatal and reproductive health (obstetrics and gynecology, maternal and fetal medicine, pediatricians, neonatologists, endocrinologists, infectious disease specialists, and neurologists) and also at health sciences professionals involved in the study of reproduction perinatal and reproductive health (chemists, biologists and neuro-physiologists). It is an electronic biannual journal, that publishes peer-reviewed original articles, in-deep reviews, letters to the editor and special sections related to basic, epidemiological, surgical, and clinical aspects in the area of perinatal and reproductive health, in English or Spanish languages and open access.