Seroprevalence of Hepatitis B Virus and Hepatitis C Virus Infections Among People with Severe Mental Illness in Tehran, Iran

IF 0.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Hepatitis Monthly Pub Date : 2022-11-03 DOI:10.5812/hepatmon-126696

Mousa Imani, H. Sharafi, A. Sadeh, Rezvan Kakavand-Ghalehnoei, S. Alavian, A. Fotouhi

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引用次数: 1

Abstract

Background: High-risk behaviors in people with severe mental illnesses, such drug injection by shared equipment and unprotected sex, expose them to the risk of blood-borne infections such as hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Objectives: This study aimed to determine the prevalence of HBV and HCV serum markers in people with severe mental illnesses in Tehran, Iran. Methods: In this cross-sectional study, people with mental illnesses, such as schizophrenia, bipolar disorder, and depression, were studied. The participants were recruited using a non-random convenience sampling method from Roozbeh and Razi hospitals in Tehran between December 2019 and March 2020. Blood samples were evaluated for HCV-Ab, HBs Ag, HBs Ab, and HBc Ab using an enzyme immunoassay technique. Results: A total of 257 participants were recruited for this study; their mean age was 35.77 years, and 70.0% of whom were male. Bipolar disorder (40.5%) and schizophrenia (35.8%) were the most frequent severe mental disorders in the participants. The prevalence of HBV and HCV seromarkers was as follows: HBs Ag: 0.3% (95% CI: 0.0 - 2.0%), HBc Ab: 7.3% (95% CI: 4.6 - 11.3%), HBs Ab: 18.7% (95% CI: 14.1 - 24.0%), and HCV Ab: 3.1% (95% CI: 1.3 - 6.9%). In logistic regression analysis, tattooing (OR = 4.94, 95% CI: 1.73 - 14.13) and age (OR= 1.06, 95% CI: 1.01 - 1.11) were associated with HBV infection (HBc Ab positivity), and only tattooing (OR= 6.33, 95% CI: 1.19 - 33.80) was significantly associated with exposure to HCV. Conclusions: The results of this study showed that the prevalence of HBsAg positivity in people with severe mental illness was not higher than that in the general population of Iran; however, HCV Ab positivity was more prevalent in people with severe mental illness than in the general population of Iran. Preventive, diagnostic, and therapeutic interventions for HCV infection are needed in this population in Iran.

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伊朗德黑兰严重精神疾病患者中乙型肝炎病毒和丙型肝炎病毒感染的血清阳性率

背景:严重精神疾病患者的高危行为，如共用设备注射药物和无保护的性行为，使他们面临血源性感染的风险，如乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染。目的:本研究旨在确定伊朗德黑兰严重精神疾病患者中HBV和HCV血清标志物的流行情况。方法:在这个横断面研究中，研究了精神疾病患者，如精神分裂症、双相情感障碍和抑郁症。参与者是在2019年12月至2020年3月期间从德黑兰的Roozbeh和Razi医院采用非随机方便抽样方法招募的。使用酶免疫测定技术评估血液样本的HCV-Ab、HBs Ag、HBs Ab和HBc Ab。结果:本研究共招募了257名参与者;平均年龄35.77岁，男性占70.0%。双相情感障碍(40.5%)和精神分裂症(35.8%)是参与者中最常见的严重精神障碍。HBV和HCV血清标记物的患病率如下:HBs Ag: 0.3% (95% CI: 0.0 - 2.0%)， HBc Ab: 7.3% (95% CI: 4.6 - 11.3%)， HBs Ab: 18.7% (95% CI: 14.1 - 24.0%)， HCV Ab: 3.1% (95% CI: 1.3 - 6.9%)。在logistic回归分析中，文身(OR= 4.94, 95% CI: 1.73 - 14.13)和年龄(OR= 1.06, 95% CI: 1.01 - 1.11)与HBV感染(HBc Ab阳性)相关，只有文身(OR= 6.33, 95% CI: 1.19 - 33.80)与HCV暴露显著相关。结论:本研究结果显示，伊朗重度精神疾病患者HBsAg阳性患病率不高于普通人群;然而，HCV - Ab阳性在伊朗严重精神疾病患者中比在普通人群中更为普遍。伊朗这一人群需要采取预防、诊断和治疗丙肝病毒感染的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatitis Monthly 医学-胃肠肝病学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Hepatitis Monthly is a clinical journal which is informative to all practitioners like gastroenterologists, hepatologists and infectious disease specialists and internists. This authoritative clinical journal was founded by Professor Seyed-Moayed Alavian in 2002. The Journal context is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates and consensus statements of the clinical relevance of hepatological field especially liver diseases. In addition, consensus evidential reports not only highlight the new observations, original research, and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in the journal.