Maximizing value and minimizing waste in clinical trial research in swine: Selecting interventions to build an evidence base

IF 0.7 4区农林科学 Q3 Agricultural and Biological Sciences

Journal of Swine Health and Production Pub Date : 2022-11-01 DOI:10.54846/jshap/1295

J. Sargeant, A. O'Connor, T. O’Sullivan, A. Ramirez

引用次数: 1

Abstract

Researchers conduct a trial to compare an intervention of interest to a comparison group. Initially, researchers should determine whether a trial is evaluating superiority, equivalence, or noninferiority. This decision will guide the choice of a placebo versus active comparison group. Interventions, as well as baseline management, should be comprehensively reported to allow replication or clinical application. It is necessary to build a body of evidence across multiple trials to apply evidence-based decision-making. To achieve this, at least one intervention in every trial should be an intervention that has been used in at least one previously published trial.

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猪临床试验研究中的价值最大化和浪费最小化:选择干预措施以建立证据基础

研究人员进行了一项试验，将感兴趣的干预措施与对照组进行比较。最初，研究人员应该确定试验是否评估优越性、等效性或非劣效性。这一决定将指导安慰剂组和积极对照组的选择。干预措施以及基线管理应全面报告，以便复制或临床应用。有必要建立一个跨多个试验的证据体，以应用基于证据的决策。为达到这一目的，每项试验中至少有一项干预措施应该是在至少一项先前发表的试验中使用过的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Swine Health and Production 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The Journal of Swine Health & Production (JSHAP) is an open-access and peer-reviewed journal published by the American Association of Swine Veterinarians (AASV) since 1993. The aim of the journal is the timely publication of peer-reviewed papers with a scope that encompasses the many domains of applied swine health and production, including the diagnosis, treatment, management, prevention and eradication of swine diseases, welfare & behavior, nutrition, public health, epidemiology, food safety, biosecurity, pharmaceuticals, antimicrobial use and resistance, reproduction, growth, systems flow, economics, and facility design. The journal provides a platform for researchers, veterinary practitioners, academics, and students to share their work with an international audience. The journal publishes information that contains an applied and practical focus and presents scientific information that is accessible to the busy veterinary practitioner as well as to the research and academic community. Hence, manuscripts with an applied focus are considered for publication, and the journal publishes original research, brief communications, case reports/series, literature reviews, commentaries, diagnostic notes, production tools, and practice tips. All manuscripts submitted to the Journal of Swine Health & Production are peer-reviewed.