Clinical manifestation and microbial profiling of recurrent MDR microorganisms associated with head and neck infection- a retrospective study

IF 0.2 Q4 HEALTH CARE SCIENCES & SERVICES
S. Lenka, Debasmita Dubey, Shakti Rath, Somadatta Das, S. Swain
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Abstract

Head and neck infection (HNI) can lead to life-threatening complications, including death. The purpose of this study is to look at the entire clinico-demographic profile of patients with HNI as well as the microbiologic profile of recurring bacterial infection cases with a variety of symptoms. A retrospective cross-sectional study was conducted on 1080 HNI patients in a tertiary care hospital in Bhubaneswar, Odisha, India, from January 2018 to December 2022. Of the 1080 cases, 771 (71.39%) were males, 309 (28.61%) were females, and 603 (55.83%) were from rural areas reporting to a tertiary care hospital. 62% of the cases were between the ages of 31 and 60. Neck abscesses account for 570 (52.78%) of all cases, with parotid abscesses accounting for 233 (21.57%), peritonsillar abscesses accounting for 170 (15.74%), otitis media 32 (2.96%), and oral cavity infection accounting for 26 (2.41%). In 854 (79.07%) cases, the etiology was odontogenic, followed by sinus in 188 (17.41%) and otogenic in 38 (3.52%). The most common presenting features were neck swelling in 537 (49.72%) cases and face swelling in 238 (22.04%) cases, followed by jaw pain in 26 (2.41%) cases and others. Patients were hospitalized for an average of 11.824.38 days. Treatment and recurrence had a strong significant relationship (p 0.001). Microbiologic investigation of recurrent patients revealed 12 microorganisms, including bacteria and fungus, mainly multidrug-resistant in given ascending order Staphylococcus aureus (26.74%), Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Candida albicans (4.65%), Aspergillus fumigatus, A. flavus, A. niger, C. tropicalis, C. glabrata, C. krusei. Apart from colistin, almost all antibiotics were highly resistant to gram-negative bacteria, whereas against S. aureus, benzylpenicillin, and oxacillin showed 100% resistance, followed by erythromycin (91.3%), levofloxacin (86.96%), and ciprofloxacin (82.61%). This exploratory study would aid in determining the HNI burden and epidemiology, as well as their treatment status.
与头颈部感染相关的复发性耐多药微生物的临床表现和微生物谱——一项回顾性研究
头颈部感染(HNI)可导致危及生命的并发症,包括死亡。本研究的目的是观察HNI患者的整个临床人口学特征,以及具有各种症状的复发性细菌感染病例的微生物学特征。2018年1月至2022年12月,对印度奥里萨邦布巴内斯瓦尔一家三级护理医院的1080名HNI患者进行了一项回顾性横断面研究。在1080例病例中,771例(71.39%)为男性,309例(28.61%)为女性,603例(55.83%)来自农村地区,向三级护理医院报告。62%的病例年龄在31岁至60岁之间。颈部脓肿570例(52.78%),腮腺脓肿233例(21.57%),扁桃体周围脓肿170例(15.74%),中耳炎32例(2.96%),口腔感染26例(2.41%),其次是鼻窦188例(17.41%)和耳源性38例(3.52%)。最常见的表现为颈部肿胀537例(49.72%)和面部肿胀238例(22.04%),其次是颌骨疼痛26例(2.41%)和其他。患者平均住院11.8243.38天。治疗与复发有着极强的显著关系(p 0.001)。对复发患者的微生物学调查显示,12种微生物,包括细菌和真菌,主要耐多药,按升序排列为金黄色葡萄球菌(26.74%)、肺炎克雷伯菌、绿脓杆菌、鲍曼不动杆菌、大肠杆菌、白色念珠菌(4.65%),烟曲霉、黄曲霉、黑曲霉、热带曲霉、光滑曲霉、克鲁塞曲霉。除粘菌素外,几乎所有抗生素对革兰氏阴性菌都具有高度耐药性,而对金黄色葡萄球菌、苄青霉素和苯唑西林的耐药性为100%,其次是红霉素(91.3%)、左氧氟沙星(86.96%)和环丙沙星(82.61%)。这项探索性研究将有助于确定HNI负担、流行病学及其治疗状况。
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来源期刊
CiteScore
0.10
自引率
0.00%
发文量
13
审稿时长
10 weeks
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