Pathological human astroglia in Alzheimer's disease: Opening new horizons with stem cell technology

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2018-05-01 DOI:10.2217/FNL-2017-0029

L. Mohamet, V. C. Jones, G. Dayanithi, A. Verkhratsky

引用次数: 8

Abstract

Pathological remodeling, degeneration and reactivity of astrocytes are fundamental astrogliopathies contributing to all neurological diseases. In neurodegenerative disorders (including Alzheimer's disease [AD]) astroglia undergo complex changes that range from atrophy with loss of function to accumulation of reactive cells around disease-specific lesions (senile plaques in the case of AD). The cellular pathology of astroglia in the context of human AD remains enigmatic; mainly because of the severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. Human-induced pluripotent stem cells technology creates a novel and potentially revolutionizing platform for studying fundamental mechanisms of the disease and for screening to identify new therapeutic compounds.

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阿尔茨海默病中的病理性人类星形胶质细胞：用干细胞技术开辟新视野

星形胶质细胞的病理重塑、变性和反应性是导致所有神经系统疾病的基本星形胶质细胞病。在神经退行性疾病（包括阿尔茨海默病[AD]）中，星形胶质细胞发生复杂的变化，从功能丧失的萎缩到疾病特异性病变周围反应性细胞的积聚（AD患者为老年斑块）。在人类AD的背景下，星形胶质细胞的细胞病理学仍然是个谜；主要是因为动物模型的严重局限性，尽管动物模型再现了疾病的一些病理特征，但并不能完全模拟疾病的进展。人类诱导多能干细胞技术为研究该疾病的基本机制和筛选新的治疗化合物创造了一个新的、潜在的革命性平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.