Polyamines, folic acid supplementation and cancerogenesis

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2017-12-20 DOI:10.1515/pterid-2017-0012

G. Bjelaković, I. Stojanovic, T. Stoimenov, D. Pavlović, G. Kocić, G. Bjelakovic, D. Sokolović, J. Bašić

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引用次数: 9

Abstract

Abstract Clinical practice and experimental studies have shown the necessity of sufficient quantities of folic acid intake for normal embryogenesis and fetal development in the prevention of neural tube defects (NTDs) and neurological malformations. So, women of childbearing age must be sure to have an adequate folate intake periconceptionally, prior to and during pregnancy. Folic acid fortification of all enriched cereal grain product flour has been implemented in many countries. Thus, hundreds of thousands of people have been exposed to an increased intake of folic acid. Folate plays an essential role in the biosynthesis of methionine. Methionine is the principal aminopropyl donor required for polyamine biosynthesis, which is up-regulated in actively growing cells, including cancer cells. Folates are important in RNA and DNA synthesis, DNA stability and integrity. Clinical and epidemiological evidence links folate deficiency to DNA damage and cancer. On the other hand, long-term folate oversupplementation leads to adverse toxic effects, resulting in the appearance of malignancy. Considering the relationship of polyamines and rapidly proliferating tissues (especially cancers), there is a need for better investigation of the relationship between the ingestion of high amounts of folic acid in food supplementation and polyamine metabolism, related to malignant processes in the human body.

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多胺、叶酸补充与癌症发生

摘要临床实践和实验研究表明，在预防神经管缺陷（NTD）和神经畸形方面，为正常胚胎发生和胎儿发育摄入足够量的叶酸是必要的。因此，育龄妇女必须确保在怀孕前和怀孕期间有足够的叶酸摄入。许多国家已经对所有富含叶酸的谷物产品面粉进行了叶酸强化。因此，数十万人暴露在叶酸摄入量增加的环境中。叶酸在蛋氨酸的生物合成中起着重要作用。甲硫氨酸是多胺生物合成所需的主要氨丙基供体，多胺在包括癌症细胞在内的活跃生长细胞中上调。叶酸在RNA和DNA合成、DNA稳定性和完整性方面很重要。临床和流行病学证据表明叶酸缺乏与DNA损伤和癌症有关。另一方面，长期叶酸过量会导致不良的毒性作用，导致恶性肿瘤的出现。考虑到多胺与快速增殖组织（尤其是癌症）的关系，有必要更好地研究在食物补充中摄入大量叶酸与多胺代谢之间的关系，多胺代谢与人体恶性过程有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.