Nanosystems for the delivery of antiretroviral drugs: opportunities, problems, and prospects

Abstract

Management of patients with an infection caused by the human immunodeficiency virus (HIV), is accompanied by difficulties of early diagnosis, expensive treatment, and the lack of specific prevention. To date, 32,7 million people worldwide have died due to the HIV epidemic from Acquired Immune Deficiency Syndrome (AIDS). One of the most important directions, to enable monitoring of viral load and extend the life expectancy of patients with HIV is to have a sufficient number of HIV treatment options available at each stage of the disease, which increases the effectiveness of treatment and allows to avoid and/or minimize the side effects of medication.The objective of this work is to review the various directions in the development of new dosage forms antiretroviral agents based nanosystems (NS) as the drugs hahavereater efficacy for the prevention and treatment of HIV infection.