А pilot project on vaccination against HPV was implemented among HIVinfected adolescents in Primorsky Krai

Abstract

Purpose: to characterize the epidemiological features of HIV infection in children in the Primorsky Territory and to analyze the results of vaccination against human papillomavirus in adolescents with HIV infection.Materials and methods. They instilled against HPV 52 HIV-infected teenagers. Three times 51 patients, two times — 1.Results. Three-fold monitoring of the level of CD4-lymphocytes and viral load (VL) of HIV was carried out before vaccination, 3 and 6 months after. In all 52 individuals, 6 months before the forthcoming vaccination, the level of CD4-lymphocytes ranged from 350 to 1925 cells in 1 ml (the average value was 857,5), VL was determined from 0 to 300 copies in 1 ml (with an average value of 64,6). During vaccination, the level of CD4-lymphocytes tended to increase and ranged from 350 to 1952 cells in 1 ml (the average value was 884,1), while the VL indices even decreased from 0 to 274 (with an average value of 53,9 copies per 1 ml). 6 months after the completed vaccination, all indicators also practically did not change: the level of CD4-lymphocytes was from 353 to 1955 cells in 1 ml (the average value was 844,5), VL from 0 to 302 (with an average value of 64,4 copies in 1 ml).Conclusion. Vaccination did not adversely affect the immune status of patients. No serious vaccine-related adverse events were observed.