Bioactive Secondary Metabolites from Aspergillus fumigatus ON428521 Isolated from Wadi El Rayan, El Fayum Governorate

Abstract

PC-3, respectively). In addition, antioxidant activity was evaluated using the DPPH radical scavenging assay, and ethyl acetate extract demonstrated moderate activity with IC 50 = 278.24 ± 8.52µg/mL, followed by petroleum ether (581.07 ± 41.95µg/mL). The phytochemical analysis showed that the ethyl acetate extract is rich in phenolics, followed by flavonoids and alkaloids while lipids are the major component of the petroleum ether extract. GC-MS analysis of petroleum ether extract gives dodecanamine, N, N-dimethyl-, lupeol acetate, amyrin, kojic acid, and oleanenol-acetate as the major components. In conclusion, ethyl acetate and petroleum ether extracts of A. fumigatus F1 exhibited moderate antimicrobial, antioxidant