The role of plant-based products in the prevention of neurological complications.

Drug metabolism letters Pub Date : 2022-04-13 DOI:10.2174/1872312815666220413095159

Ankul Singh S, Chitra V

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Abstract

Background: Neurological complications are most likely to be fatal and cause loss of ability to function or care for self. These include Alzheimer's disease and cognitive impairment. The main aim of the review is to determine the effects of various drugs and their cognitive risk with the need to opt for herbal therapy as an adjuvant in treating neurological conditions like Alzheimer's disease with lesser-known side effects. The Methodology: Involved a detailed literature survey which was performed through an online database, such as Science Direct, Google Scholar, Scopus, Cochrane, and PubMed. The study included randomized trials and original research conducted by herbal supplements on animal models to assess expression of upregulation of signalling pathways. Various studies involved in treating dementia, neurological disorders, Alzheimer disease, cognitive dysfunction were included.

Results: Found that various studies involved plant-based products were showing improvement in prevention of disease and signalling pathways with lesser-known side effects.

Conclusion: It was observed that plant-based products play a major role in the prevention of neurological complications. Herbal medicines could most suitably prevent Alzheimer's risk with less known side effects in contrast with the existing treatment patterns. However, to improve the utility of herbal medicines, more evidences from in vitro, in vivo, and clinical trials need to be addressed.

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植物性产品在预防神经系统并发症中的作用。

背景:神经系统并发症最有可能是致命的，并导致丧失功能或自我照顾的能力。这些疾病包括阿尔茨海默病和认知障碍。该综述的主要目的是确定各种药物的效果及其认知风险，以及选择草药疗法作为辅助治疗阿尔茨海默病等副作用鲜为人知的神经系统疾病的必要性。方法:通过Science Direct、谷歌Scholar、Scopus、Cochrane和PubMed等在线数据库进行详细的文献调查。该研究包括随机试验和通过草药补充剂在动物模型上进行的原始研究，以评估信号通路上调的表达。包括治疗痴呆、神经紊乱、阿尔茨海默病和认知功能障碍的各种研究。结果发现，涉及植物性产品的各种研究显示，植物性产品在预防疾病和信号通路方面有所改善，副作用鲜为人知。结论植物性产品在预防神经系统并发症中起重要作用。与现有的治疗模式相比，草药可以最适当地预防阿尔茨海默氏症的风险，其副作用鲜为人知。然而，为了提高草药的效用，需要解决更多来自体外、体内和临床试验的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug metabolism letters Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

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期刊介绍： Drug Metabolism Letters publishes letters and research articles on major advances in all areas of drug metabolism and disposition. The emphasis is on publishing quality papers very rapidly by taking full advantage of the Internet technology both for the submission and review of manuscripts. The journal covers the following areas: In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites.