Efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: A case report

世界血液学杂志 Pub Date : 2022-02-25 DOI:10.5315/wjh.v9.i1.6

Qian Gao, Xiaowei Xin, Chunli Zhao, Yujuan Wang, Wei Wang, Yi Yin, Xiaoru Wang, You-peng Jin

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Abstract

Abstract BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a severe and potentially deadly condition associated with extensive inflammation and immune activation. Cytokine adsorption may serve as a supportive treatment that can stabilize organ function in affected patients by reducing their circulating cytokines levels. To date, no descriptions of clinical experiences associated with the use of HA330-II column hemoadsorption for the treatment of HLH children have been published. CASE SUMMARY We describe a 11-year-old children with Epstein-Barr virus (EBV)-associated HLH combined with liver failure. She underwent HA330-II column hemoadsorption and chemotherapy, and developed a decreased inflammatory cytokines including interleukin (IL)-6, IL-8, IL-10, and interferon (IFN)-γ. The patient’ condition and laboratory parameters gradually improved. CONCLUSION Hemoadsorption may play an important role in eliminating cytokines storm in children with Hemophagocytic lymphohistiocytosis combined with liver failure and consequent multiple organ failure.

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HA330-II柱吸附治疗EB病毒相关性噬血细胞性淋巴组织细胞增多症合并肝功能衰竭1例

摘要背景吞噬性淋巴组织细胞增多症（HLH）是一种严重且潜在的致命疾病，与广泛的炎症和免疫激活有关。细胞因子吸附可以作为一种支持性治疗，通过降低循环细胞因子水平来稳定受影响患者的器官功能。到目前为止，还没有关于使用HA330-II柱血液吸附治疗HLH儿童的临床经验的描述发表。病例摘要：我们描述了一名11岁的儿童，患有EB病毒相关的HLH并伴有肝衰竭。她接受了HA330-II柱血液吸附和化疗，并产生了减少的炎症细胞因子，包括白细胞介素（IL）-6、IL-8、IL-10和干扰素（IFN）-γ。患者的病情和实验室参数逐渐好转。结论血液吸附可能在消除儿童吞噬细胞性淋巴组织细胞增多症合并肝功能衰竭及多器官功能衰竭的细胞因子风暴中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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世界血液学杂志

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