Development Michrosphere Bioadhesive Delivery System From Secondary Metabolit Actynomycetes M10a Rhizosphere Mangrove As Supportive Therapy of Colon Cancer Patients

Abstract

Colon cancer is a cancer that occurs in the large intestine when abnormal cells grow in the colon or rectum layer.  Inflammation Symptoms  in the colon are usually characterized by a polyp that has cancer risk. Approximately 96% of colon cancer cases are caused by adenocarcinomas that develop from the glandular tissue. Utilization of secondary metabolites from Actynomycetes Mangrove forests can be used as supportive therapy for colon cancer patients that have already through apoptotic testing so it can directly treat the target of illness. This  study was prepared in the form of  Michrosphere Bioadhesive  using secondary metabolite  Actynomycetes M10a rhizosphere mangrove. The purpose of this study was to obtain the development of  Michosphere Bioadhesive  preparations from secondary metabolites  Actynomycetes M10a  rhizosphere mangrove  as supportive therapy for colon cancer patients. Method of the research is base on Laboratory experiment which started with Purification  of  Actynomycetes  isolate, Secondary Metabolite Fermentation,  Michrosphere Bioadhesive  Formulation and evaluation of  Michrosphere  Bioadhesive  preparation. The concentration of secondary metabolite Actynomycetes M10a rhizosphere mangrove that been used for each formula are 400 μl, 500 μl, and 600 μl, where the percentage of submerged in F1, F2, and F3 are 93,94%, 96,96%, and 94, respectively, 12%. Particular Particle Size Distribution is F1 (3.1μm), F2 (4.4 μm), F3 (3.9 μm). The rest angles obtained are F1 (0.002O), F2 (0.002O), F3 (0.0016O), respectively. Applied efficiency was obtained by F1 (214 nm), F2 (210 nm), F3 (211 nm). Dissolution results show the absorbance results at 266 nm wavelength. From the results obtained that meet the specifications seen in Formula 2.  Keywords: Colon Cancer,  Actynomycetes  M10a  rhizosphere mangrove, Michosphere Bioadhesive.