Diabetic nephropathy ameliorated in patients with normal home blood pressure compared to those with isolated high home systolic blood pressure: A 5-year prospective cohort study among patients with type 2 diabetes mellitus

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2022-05-01 DOI:10.1177/14791641221098193

Nobuko Kitagawa, E. Ushigome, Noriyuki Kitagawa, H. Ushigome, Isao Yokota, Naoko Nakanishi, M. Hamaguchi, M. Asano, M. Yamazaki, M. Fukui

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引用次数: 1

Abstract

Background: Using normal home blood pressure (home BP) as a reference, isolated high home systolic blood pressure (IH-home SBP) increases the risk of diabetic nephropathy. However, whether diabetic nephropathy would improve among diabetic patients without IH-home SBP has not been previously assessed. Methods: This prospective 5-year cohort study of 264 patients with moderate or severe albuminuria investigated the effect of IH-home SBP or normal home BP on the risk of diabetic nephropathy in patients with type 2 diabetes mellitus. Improvement of diabetic nephropathy was defined as remission or regression from moderate or severe albuminuria to normal or mildly increased albuminuria. Results: Improvement of diabetic nephropathy was shown in 59 out of 264 patients during 5 years. The adjusted odds ratio (95% confidence interval) of normal home BP for improving diabetic nephropathy was 2.52 (1.01–5.99, p = 0.05). Conclusion: Normal home BP had relation to an improvement in diabetic nephropathy among type 2 diabetic patients with moderate and severe increased albuminuria in the observation period of 5 years. Good home BP control might be valuable to ameliorate diabetic nephropathy.

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与孤立的家庭收缩压高患者相比，家庭血压正常患者的糖尿病肾病得到改善：一项针对2型糖尿病患者的5年前瞻性队列研究

背景：以正常家庭血压（home BP）为参考，孤立的高家庭收缩压（IH home SBP）会增加糖尿病肾病的风险。然而，在没有IH家庭SBP的糖尿病患者中，糖尿病肾病是否会改善，此前尚未进行评估。方法：这项针对264名中重度蛋白尿患者的前瞻性5年队列研究调查了IH家庭SBP或正常家庭BP对2型糖尿病患者糖尿病肾病风险的影响。糖尿病肾病的改善被定义为从中度或重度蛋白尿缓解或消退为正常或轻度增加的蛋白尿。结果：264例糖尿病肾病患者中有59例在5年内得到改善。正常家庭血压改善糖尿病肾病的校正比值比（95%置信区间）为2.52（1.01–5.99，p=0.05）。结论：在5年的观察期内，在蛋白尿中度和重度增加的2型糖尿病患者中，正常家庭血压与糖尿病肾病的改善有关。良好的家庭血压控制可能对改善糖尿病肾病有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)