Effect of Two Mucoprotectants, Gelatin Tannate and Xyloglucan plus Gelatin, on Cholera Toxin-Induced Water Secretion in Rats

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal disorders (Basel, Switzerland) Pub Date : 2022-12-13 DOI:10.3390/gidisord4040030

H. Eutamene, C. Beaufrand, C. Harkat, V. Théodorou

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引用次数: 1

Abstract

Background: Newer antidiarrheal agents include the mucoprotectants gelatin tannate and xyloglucan. Methods: Rat models of cholera toxin (CT)-induced water secretion were used to evaluate the mucoprotective effects of gelatin tannate, xyloglucan, and related compounds. Results: Oral pretreatment for 4 days with gelatin tannate (250 and 500 mg/kg/day), but not tannic acid or gelatin (both 125 mg/kg/day), blocked CT-induced intestinal water secretion. CT-induced intestinal water secretion was also attenuated by oral xyloglucan 12.5 mg/kg + gelatin 125 mg/kg (6 h pre-CT) and gelatin 250 mg/kg (12 h pre-CT), and by local (intra-jejunal loop) administration of gelatin, gelatin tannate and xyloglucan concomitantly with CT. Conclusions: Gelatin tannate and xyloglucan + gelatin attenuated CT-induced intra-loop water secretion in this experimental model, supporting previous evidence that their mechanisms of mucosal protection are closely related to their chemical structures, which confer film-forming properties via the formation of mucoadhesive films.

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明胶单宁和木葡糖聚糖加明胶两种粘膜保护剂对霍乱毒素诱导大鼠水分泌的影响

背景：较新的止泻剂包括粘膜保护剂鞣酸明胶和木葡聚糖。方法：采用霍乱毒素（CT）诱导的大鼠水分泌模型，评价鞣酸明胶、木葡聚糖及其相关化合物的粘膜保护作用。结果：用鞣酸明胶（250和500mg/kg/天）口服预处理4天，而不用鞣酸或明胶（均为125mg/kg/天），阻断了CT诱导的肠道水分分泌。口服木葡聚糖12.5 mg/kg+明胶125 mg/kg（CT前6小时）和明胶250 mg/kg（CT后12小时），以及在CT的同时局部（空肠内）给予明胶、鞣酸明胶和木葡聚糖，也会减弱CT诱导的肠道水分分泌。结论：在该实验模型中，明胶单宁酸盐和木葡聚糖+明胶减弱了CT诱导的环内水分泌，支持了先前的证据，即它们的粘膜保护机制与其化学结构密切相关，化学结构通过形成粘膜粘附膜赋予成膜特性。

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来源期刊

Gastrointestinal disorders (Basel, Switzerland)

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

10 weeks