PREVALENCE OF PHENOTYPIC CARBAPENEM-RESISTANT ENTEROBACTERALES ISOLATES AND THEIR DISTRIBUTION BY SEX, AGE GROUPS, STATE AND SPECIES IN SOUTH-EAST NIGERIA

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL

Gomal Journal of Medical Sciences Pub Date : 2022-06-30 DOI:10.46903/gjms/20.02.1127

Uchenna I. Ugah, T. K. Udeani

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Abstract

Background: Carbapenems are broad spectrum β-lactam antibiotics that were introduced in response to the emergence of ESBL-producing Gram-negative bacteria. This study aimed at determining the occurence of carbapenem resistant Enterobacterales isolates among patients attending five tertiary hospitals with southeastern region of Nigeria. Methods: A total of 400 Enterobacterales were isolated from different participants. Carbapenem-resistance was detected using Kirby-Bauer disc diffusion method with ertapenem, meropenem, imipenem, and doripenem. Results: A total of 117 isolates (29.2%) were resistant to the four carbapenems. When compared among the states, the prevalence were 33.6%, 29.1%, 28.8%, 26.9% and 24.7% for Enugu, Ebonyi, Imo, Anambra and Abia states respectively. The highest resistance was observed among P. mirabilis (52.6%) followed by K. oxytoca (35.7%), S. enterica (35.7%) and K. pneumoniae (33.8%). Conclusion: The overall prevalence was high and this is a cause for concern and urgent need for emergency intervention to forestall widespread emergence of pandrug resistant infections.

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尼日利亚东南部表型耐碳青霉烯类肠杆菌分离株的流行及其按性别、年龄组、州和物种的分布

背景：碳青霉烯类抗生素是针对产ESBL的革兰氏阴性菌的出现而引入的广谱β-内酰胺类抗生素。本研究旨在确定在尼日利亚东南部地区五家三级医院就诊的患者中出现的碳青霉烯类耐药肠杆菌分离株。方法：从不同的参与者中共分离出400株肠杆菌。采用Kirby-Bauer圆盘扩散法，用厄他培南、美罗培南、亚胺培南和多里培烯检测碳青霉烯耐药性。结果：共有117株（29.2%）菌株对四种碳青霉烯类化合物产生耐药性。在各州之间进行比较时，埃努古州、埃博尼州、伊莫州、阿南布拉州和阿比亚州的患病率分别为33.6%、29.1%、28.8%、26.9%和24.7%。奇异假单胞菌的耐药性最高（52.6%），其次是氧化假单胞菌（35.7%）、肠炎沙门氏菌（35.3%）和肺炎克雷伯菌（33.8%）。

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