Highly sensitive modified giant magnetometer resistance measurement system for the determination of superparamagnetic nanoparticles in continuous flow with application for the separation of biomarkers

IF 1.3 4区工程技术 Q4 CHEMISTRY, ANALYTICAL

Instrumentation Science & Technology Pub Date : 2022-11-07 DOI:10.1080/10739149.2022.2143374

Ma Xuan, Phu Nguyen Dang, Loc Do Quang, Hiếu Nguyễn Minh, T. C. Duc, T. Thanh

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引用次数: 1

Abstract

Abstract A highly sensitive magnetic measurement system was successfully developed using a modified commercial giant magnetometer resistance (GMR) sensor. The device was placed in a highly uniform magnetic field that was generated by two Helmholtz coil pairs which emit magnetic fields in perpendicular directions to magnetize the SPMNPs and bias the GMR sensor to a linear operating range. The system was used to quantitatively determine the concentrations of superparamagnetic nanoparticles in continuous flow. The characteristics of the proposed system were investigated using three types of superparamagnetic nanoparticles: CoFe2O4, CoFe2O4@Fe3O4, and Fe3O4 with different average particle sizes and magnetic saturation. Coupled with the lock-in measurements, the limit of detection (LOD) for the Fe3O4 nanoparticles was 15.5 μg/mL. The limits of detection for CoFe2O4 and CoFe2O4@Fe3O4 were 74 μg/mL and 96.5 μg/mL, respectively. The results show that Fe3O4 is suitable for this system for the separation and quantification of biomarkers in diagnostics.

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高灵敏度改良巨磁计电阻测量系统用于连续流动超顺磁性纳米颗粒的测定，应用于生物标志物的分离

摘要利用改进的商用巨磁电阻传感器成功开发了一种高灵敏度的磁测量系统。该装置被放置在由两对亥姆霍兹线圈产生的高度均匀的磁场中，这两对线圈在垂直方向上发射磁场以磁化SPMNP并将GMR传感器偏置到线性工作范围。该系统用于定量测定连续流动中超顺磁性纳米颗粒的浓度。使用三种类型的超顺磁性纳米颗粒：CoFe2O4，CoFe2O4@Fe3O4和具有不同平均粒径和磁饱和度的Fe3O4。结合锁定测量，Fe3O4纳米颗粒的检测限（LOD）为15.5 μg/mL。CoFe2O4和CoFe2O4@Fe3O4是74 μg/mL和96.5 μg/mL。结果表明，Fe3O4适用于该系统，用于诊断中生物标志物的分离和定量。

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来源期刊

Instrumentation Science & Technology 工程技术-分析化学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Instrumentation Science & Technology is an internationally acclaimed forum for fast publication of critical, peer reviewed manuscripts dealing with innovative instrument design and applications in chemistry, physics biotechnology and environmental science. Particular attention is given to state-of-the-art developments and their rapid communication to the scientific community. Emphasis is on modern instrumental concepts, though not exclusively, including detectors, sensors, data acquisition and processing, instrument control, chromatography, electrochemistry, spectroscopy of all types, electrophoresis, radiometry, relaxation methods, thermal analysis, physical property measurements, surface physics, membrane technology, microcomputer design, chip-based processes, and more. Readership includes everyone who uses instrumental techniques to conduct their research and development. They are chemists (organic, inorganic, physical, analytical, nuclear, quality control) biochemists, biotechnologists, engineers, and physicists in all of the instrumental disciplines mentioned above, in both the laboratory and chemical production environments. The journal is an important resource of instrument design and applications data.