Anxiety and Depression Among Patients with Predominantly Antibody Deficiencies and the Importance of Early Diagnosis

IF 0.3 Q4 ALLERGY

Astim Allerji Immunoloji Pub Date : 2021-08-23 DOI:10.21911/aai.612

S. Yeşillik, F. Demirel

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Abstract

ABSTRACT Objective: Diagnostic delay is one of the major problems for patients with predominantly antibody deficiencies (PAD) that can lead to anxiety and depression disorders, like in other chronic diseases. We aimed to detect the frequencies of anxiety and depression in PAD patients. The second aim was to determine the influence of diagnosis delay on the patients’ anxiety and depression. Materials and Methods: In this prospective study, 40 patients and 50 healthy controls answered the Hospital Anxiety and Depression Scale (HADS). We compared the anxiety, depression, and the total scores of the patients and the healthy controls. We divided the patients into two groups as delayed and early diagnosed patients according to median diagnostic delay year and compared the HADS scores of the two groups. Results: The anxiety, depression and the total scores of PAD patients were significantly higher compared to the healthy controls; (p=0.001, p=0.001, p=0.001), respectively. The HADS scores were significantly higher in the delayed diagnosis patient group than the early diagnosed patient group (p=0.001, p=0.003, p=0.001), respectively. We also confirmed this positive relationship between delayed diagnosis and the HADS scores with Spearman’s correlation analysis. Conclusion: We demonstrated that psychiatric disorders such as anxiety and depression are common in PAD patients, and delayed diagnosis strongly affects their anxiety and depression. Collaboration with psychologists and psychiatrists during the management of these patients may improve the quality of their life. Keywords: Predominantly antibody deficiencies, early diagnosis, anxiety, depression

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主要抗体缺乏患者的焦虑和抑郁情绪及早期诊断的重要性

摘要目的：与其他慢性疾病一样，抗体缺乏症（PAD）患者的主要问题之一是诊断延迟，PAD可导致焦虑和抑郁障碍。我们旨在检测PAD患者焦虑和抑郁的频率。第二个目的是确定诊断延迟对患者焦虑和抑郁的影响。材料和方法：在这项前瞻性研究中，40名患者和50名健康对照回答了医院焦虑和抑郁量表（HADS）。我们比较了患者和健康对照组的焦虑、抑郁和总分。我们根据中位诊断延迟年将患者分为延迟诊断和早期诊断两组，并比较两组的HADS评分。结果：PAD患者的焦虑、抑郁及总分均明显高于健康对照组；（p=0.001，p=0.001，p=0.001）。延迟诊断患者组的HADS评分分别显著高于早期诊断患者组（p=0.001，p=0.003，p=0.001）。我们还通过Spearman相关分析证实了延迟诊断与HADS评分之间的正相关关系。结论：PAD患者常见焦虑、抑郁等精神障碍，延迟诊断严重影响患者的焦虑、抑郁情绪。在管理这些患者的过程中，与心理学家和精神病学家合作可以提高他们的生活质量。关键词：主要抗体缺乏、早期诊断、焦虑、抑郁

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Astim Allerji Immunoloji ALLERGY-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Asthma Allergy Immunology has been published three times a year in April, August and December as the official and periodical journal of the Turkish National Society of Allergy and Clinical Immunology since 2003. All articles published in the journal have been available online since 2003. A peer reviewed system is used in evaluation of the manuscripts submitted to Asthma Allergy Immunology. The official language of the journal is English. The aim of the journal is to present advances in the field of allergic diseases and clinical immunology to the readers. In accordance with this goal, manuscripts in the format of original research, review, case report, articles about clinical and practical applications and editorials, short report and letters to the editor about allergic diseases and clinical immunology are published in the journal. The target reader population of the Asthma Allergy Immunology includes specialists and residents of allergy and clinical immunology, pulmonology, internal medicine, pediatrics, dermatology and otolaryngology as well as physicians working in other fields of medicine interested in allergy and immunological diseases.