An investigation into the effects of excipients on quality characteristics of a dry herbal extract containing capsule

IF 0.8 4区 工程技术 Q4 ENGINEERING, CHEMICAL
Branka Grujić, Z. Vuković, Jelena Veljković‐Giga, S. Ibrić, D. Dekanski
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引用次数: 0

Abstract

Nutrition and dietary supplements have a significant role in the prevention and treatment of cardiovascular disease. Olive and vine leaves, thanks to their constituents, represent powerful natural antioxidants exhibiting cardioprotective activity. High concentrations of active ingredients can be provided by means of extraction. Dry herbal extracts are highly sensitive to moisture and elevated temperature and from the pharmaceutical and technological point of view these are raw materials with inadequate technological properties. The aim of this study was to investigate and to compare the influence of different excipients in capsule formulation of these two dry extracts i.e. the selection of excipients that will ensure appropriate critical process parameters in the manufacturing procedure. The monitored quality characteristics include flowability, bulk density and tapped density that are critical for technological feasibility of the capsule-filling operation. The effects of excipients on the above parameters have been experimentally studied and the appropriate capsule formulations have been developed based on the obtained results, which will ensure homogeneity and stability of the preparation.
辅料对含胶囊干提取物质量特性影响的研究
营养和膳食补充剂在预防和治疗心血管疾病方面具有重要作用。橄榄和葡萄叶,由于其成分,代表了强大的天然抗氧化剂,表现出保护心脏的活性。通过萃取可以提供高浓度的有效成分。干草本提取物对水分和高温高度敏感,从制药和技术的角度来看,这些原料的技术性能不足。本研究的目的是调查和比较不同辅料对这两种干提取物胶囊配方的影响,即辅料的选择将确保生产过程中适当的关键工艺参数。监测的质量特征包括流动性、容重和出碴密度,这对胶囊充填作业的技术可行性至关重要。实验研究了辅料对上述参数的影响,并根据所得结果研制了合适的胶囊配方,保证了制剂的均匀性和稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hemijska Industrija
Hemijska Industrija 工程技术-工程:化工
CiteScore
1.60
自引率
11.10%
发文量
12
审稿时长
6-12 weeks
期刊介绍: The Journal Hemijska industrija (abbreviation Hem. Ind.) is publishing papers in the field of Chemical Engineering (Transport phenomena; Process Modeling, Simulation and Optimization; Thermodynamics; Separation Processes; Reactor Engineering; Electrochemical Engineering; Petrochemical Engineering), Biochemical Engineering (Bioreactors; Protein Engineering; Kinetics of Bioprocesses), Engineering of Materials (Polymers; Metal materials; Non-metal materials; Biomaterials), Environmental Engineeringand Applied Chemistry. The journal is published bimonthly by the Association of Chemical Engineers of Serbia (a member of EFCE - European Federation of Chemical Engineering). In addition to professional articles of importance to industry, scientific research papers are published, not only from our country but from all over the world. It also contains topics such as business news, science and technology news, information on new apparatus and equipment, and articles on environmental protection.
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