Correlations of mechanical power and its components with age and its interference in the outcome of SARS-CoV-2 in subjects undergoing pressure-controlled ventilation

Abstract

Introduction SARS-CoV-2 may be associated with ARDS and the VILI. However, there are still doubts about the correlations and the interference of tidal energy in the outcomes. The objective of this study was to verify the correlations and interference of mechanical power and its components with age in the outcome in SARS-CoV-2 of subjects undergoing pressure-controlled ventilation (PCV). Method Longitudinal, prospective, observational, analytical, and quantitative study of the information collected on two parameters of the mechanical ventilator, to calculate the mechanical power by Becher formula in 163 subjects with SARS-CoV-2 and moderate ARDS between May 2021 to September 2021. Results Correlations were found between mechanical power and its components, except for compliance (P 0.234), elastance (P 0.515), resistance (P 0.570) and age (P 0.180). There was a significant impact on the outcome in the univariate analysis of age, as well as of mechanical power and its components, except for positive end expiratory pressure (PEEP) (P 0.874), minute ventilation (Ve) (P 0.437), resistive pressure (PResist) (P 0.410) and resistance (P 0.071). The multivariate analysis of mechanical power, plateau pressure (PPlateau), tidal volume (VT), driving pressure (ΔP) and elastance, showed that only mechanical power correlated to death (P 0.04) and for each additional unit in J/minute there is a 6.2% increase in the odds of death (95% IC 0.3%; 12.4%). Conclusion There are correlations between mechanical power and its components, except for compliance, elastance, resistance, and age. There is interference in the outcome in the univariate analysis of age, as well as of mechanical power and its components, except PEEP, Ve, PResist and resistance, but the multivariate analysis showed that only mechanical power correlates with the outcome in SARS-CoV-2 undergoing PCV. Keywords: SARS-CoV-2 infection; Mortality; Ventilation Induced Lung Injury; Acute Respiratory Distress Syndrome