The Role of Cortisol in the Development of Post-Stroke Dementia: A Narrative Review

IF 1 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Heart and Mind Pub Date : 2022-07-01 DOI:10.4103/hm.hm_32_22
Isabella Edwards, I. Singh, R. Rose'meyer
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引用次数: 3

Abstract

Stroke is defined as a neurological deficit which lasts more than 24 h or leads to death, which is caused by a focal acute injury to the central nervous system with a vascular origin. Strokes are one of the greatest challenges in public health. As an acutely stressful event, strokes have been associated with an increased release in the stress hormone cortisol. Elevated cortisol has been linked to deleterious impacts on the brain, particularly the hippocampus, and has been associated with the development of dementia, though the mechanisms behind this remain unclear. Dementia is also an important stroke outcome, affecting approximately a third of stroke survivors in the long term. This review explores the relationship between strokes and cortisol, to determine the association between cortisol and hippocampal/neuronal damage and poststroke dementia and cortisol.
皮质醇在脑卒中后痴呆发展中的作用:叙述性综述
中风被定义为由血管源性中枢神经系统局灶性急性损伤引起的持续24小时以上或导致死亡的神经功能缺损。中风是公共卫生领域最大的挑战之一。作为一种急性应激事件,中风与应激激素皮质醇的释放增加有关。皮质醇升高与大脑,尤其是海马体的有害影响有关,并与痴呆症的发展有关,尽管其背后的机制尚不清楚。痴呆症也是中风的一个重要后果,长期影响约三分之一的中风幸存者。这篇综述探讨了中风和皮质醇之间的关系,以确定皮质醇与海马/神经元损伤以及中风后痴呆和皮质醇之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
10
审稿时长
19 weeks
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