Cardiovascular Changes in Normo and Hypogonadal Rats Treated with a High-Fructose Diet and Induced Hyperuricemia Condition

Endocrinology, diabetes and metabolism journal Pub Date : 2019-04-20 DOI:10.31038/edmj.2019332

J. Soutelo, Y. Samaniego, MC Fornari, C. ReyesToso, Ponzo OJ Ph

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Abstract

Objective: to evaluate the presence and type of cardiovascular damage in normogonadic and hypogonadic male rats with a induced condition of mild hyperuricemia and exposed to a high-fructose diet. Methods: Fifty six (56) male adult Wistar rats were used in the present work. Animals were divided into two groups; normogonadic (NGN) and hypogonadic (HGN), and each group was divided into four subgroups according to their treatment: control with only water (C), Fructose (F), Oxonic acid (OA) and Fructose plus Oxonic acid (FOA). Cardiovascular changes were evaluated by measuring systolic blood pressure , myocyte volume, fibrosis and intima media of aorta. Results: The FOA group significantly increased blood pressure, myocyte volume (p<0.0001), the percentage of fibrosis was significant in the group receiving OA (p<0.001). When comparing NGN vs HGN, hypogonadic animals showed a less favorable lipid profile. Conclusion: Hypogonadic, hyperuricemic conditions and a high-fructose diet favor blood pressure increase , along with changes in the cardiac hypertrophy, fibrosis and thickness increase of the intima media.

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高果糖饮食和诱导高尿酸血症对正常和性腺功能低下大鼠心血管的影响

目的：评估性腺正常和性腺功能低下的雄性大鼠在轻度高尿酸血症诱导条件下暴露于高果糖饮食时心血管损伤的存在和类型。方法：选用56只雄性成年Wistar大鼠。将动物分为两组；性腺正常（NGN）和性腺功能减退（HGN），每组根据治疗分为四个亚组：仅用水对照（C）、果糖对照（F）、草酸对照（OA）和果糖加草酸对照（FOA）。通过测量收缩压、心肌细胞体积、纤维化和主动脉内膜介质来评估心血管变化。结果：FOA组显著增加了血压、肌细胞体积（p＜0.0001），OA组的纤维化百分比显著增加（p＜0.001）。当比较NGN与HGN时，性腺功能减退的动物表现出不太好的脂质状况。结论：性腺功能低下、高尿酸血症和高果糖饮食有利于血压升高，同时伴有心脏肥大、纤维化和内膜中膜厚度增加的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Endocrinology, diabetes and metabolism journal

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