Detoxification and adaptation mechanisms of Trichoderma atroviride to antifungal agents

IF 0.9 Q4 CHEMISTRY, MULTIDISCIPLINARY
Zuzana Kubová, Tomáš Pagáč, J. Víglaš, P. Olejníková
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引用次数: 1

Abstract

Abstract Filamentous fungi are crucial for recycling of organic material in nature. In natural habitats, they cope with many stress factors and therefore their adaptation ability to various conditions is very high. Trichoderma sp., fungi used in agriculture as biocontrol agent, are exposed to a variety of toxic molecules including pesticides and fungicides. They have to fight with toxic molecules using stress adaptation mechanisms known as the stress response. Adaptation of fungi to stress, especially to chemical stress, is not well studied in environmental fungal strains. Moreover, the adaptation process presents a risk of resistance mechanism induction to antifungal agents. Such resistant strains could be spread in the environment. This work aims to contribute to the knowledge of the adaptation process spread throughout the fungal kingdom. Transcriptional response of ABC transporters, the main detoxification efflux pumps of subfamily B and G in presence of antifungal agents, is shown. On the other hand, as azoles are the most commonly used antifungal structures in clinical practice and agriculture, changes in important fungal ergosterol biosynthesis genes as a result of their exposure to various azoles structure are highlighted.
萎缩木霉对抗真菌药物的解毒作用及适应机制
摘要丝状真菌对自然界有机物质的回收利用至关重要。在自然栖息地,它们要应对许多压力因素,因此它们对各种条件的适应能力非常高。木霉(Trichoderma sp.)是一种在农业中用作生物防治剂的真菌,暴露在包括杀虫剂和杀菌剂在内的多种有毒分子中。它们必须利用被称为应激反应的应激适应机制来对抗有毒分子。真菌对胁迫的适应,特别是对化学胁迫的适应在环境真菌菌株中没有得到很好的研究。此外,适应过程存在抗真菌药物耐药性机制诱导的风险。这种抗性菌株可能在环境中传播。这项工作旨在为了解真菌界的适应过程做出贡献。ABC转运蛋白是B和G亚家族的主要解毒外排泵,在抗真菌药物存在下表现出转录反应。另一方面,由于唑类化合物是临床实践和农业中最常用的抗真菌结构,因此强调了由于暴露于各种唑类化合物结构而导致的重要真菌麦角甾醇生物合成基因的变化。
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来源期刊
Acta Chimica Slovaca
Acta Chimica Slovaca CHEMISTRY, MULTIDISCIPLINARY-
自引率
12.50%
发文量
11
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