A Round of Applause: A Review of the Applause Sign

Abstract

The applause sign is a tendency to continue applauding following a request to clap three times after demonstration, and its occurrence has been related to multiple neurological disorders. This review aims to outline the disorders in which the phenomenon was described and propose a pathophysiological mechanism for its basis considering the pattern of affection. A review of MEDLINE was performed with the inclusion of relevant data from each article. Progressive supranuclear palsy and other parkinsonian disorders and fronto-temporal