{"title":"Issue Information TOC","authors":"","doi":"10.1002/cpch.57","DOIUrl":null,"url":null,"abstract":"<p><b>Cover</b>: In DeMeester et al. (https://doi.org/10.1002/cpch.74), PG biosynthesis begins with formation of UDP-NAM through MurA/B and UDP-NAG. Recycling enzymes AmgK/MurU provide another route to synthesize UDP-NAM with NAM as the building block. UDP-NAM is converted into Park's nucleotide through enzymes MurC-F. MraY links Park's nucleotide to the cell membrane, where MurG then glycosylates this Lipid I fragment to form Lipid II. MurJ transports Lipid II into the periplasmic space, where transglycosylases (TGase) and transpeptidases (TPase) further crosslink these molecules to form mature PG. NAM probes (blue) with bioorthogonal functionality at the 2-<i>N</i> position (X) or 3-lactic acid position (Y) are metabolically incorporated into PG through both recycling and biosynthetic machineries.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":38051,"journal":{"name":"Current protocols in chemical biology","volume":"11 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cpch.57","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current protocols in chemical biology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cpch.57","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Cover: In DeMeester et al. (https://doi.org/10.1002/cpch.74), PG biosynthesis begins with formation of UDP-NAM through MurA/B and UDP-NAG. Recycling enzymes AmgK/MurU provide another route to synthesize UDP-NAM with NAM as the building block. UDP-NAM is converted into Park's nucleotide through enzymes MurC-F. MraY links Park's nucleotide to the cell membrane, where MurG then glycosylates this Lipid I fragment to form Lipid II. MurJ transports Lipid II into the periplasmic space, where transglycosylases (TGase) and transpeptidases (TPase) further crosslink these molecules to form mature PG. NAM probes (blue) with bioorthogonal functionality at the 2-N position (X) or 3-lactic acid position (Y) are metabolically incorporated into PG through both recycling and biosynthetic machineries.
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