Diversity of human papillomavirus typing among women population living in rural and remote areas of Brazilian territory

IF 3.2

Papillomavirus Research Pub Date : 2019-12-01 DOI:10.1016/j.pvr.2019.100186

Adriana Tarlá Lorenzi , José Humberto Fregnani , Luisa Lina Villa , Laura Sichero , Emily Montosa Nunes , Adhemar Longatto-Filho

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引用次数: 5

Abstract

Objectives

Genotyping HPV from samples tested positive to careHPV™ assay in rural and remote areas of Brazilian territory.

Methods

A total of 5079 women were enrolled in an opportunistic screening from the Barretos Cancer Hospital, through mobile units or ambulatory unit. All careHPV™ hr-HPV positive samples were tested by a Luminex-based protocol in order to evaluate the HPV infecting types.

Results

Positive hr-HPV results were obtained in 10.6% (536/5068) of women. Among these cases, HPV-56 and HPV-51 were the most common types detected in 32.3% and 31.4%, respectively. HPV-53 (20.5%), HPV-18 (18.5%), HPV-58 (17.6%), HPV-52 (16.0%) and HPV-16.6%) were the other most frequent types detected. These frequencies represent prevalences of 2.35%, 2.12%, 2.02%, 1.84% and 1.80% respectively, within the population studied. Regarding low-risk HPVs, HPV-6 was detected in 12.9% of the samples. The less frequent types (<3%) were: HPV-70, HPV-11 and HPV-26.

Conclusions

The most frequent types detected were: HPV-56, HPV-51, HPV-53, HPV-18, HPV-58, HPV-52 and HPV-16 according to decreasing rates.

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巴西农村和偏远地区妇女人群中人乳头瘤病毒分型的多样性

目的对巴西农村和偏远地区careHPV™检测阳性样本进行HPV基因分型。方法共有5079名妇女参加了巴雷托斯肿瘤医院通过流动单位或门诊单位进行的机会性筛查。所有careHPV™hr-HPV阳性样本通过基于luminex的方案进行检测，以评估HPV感染类型。结果10.6%(536/5068)女性hr-HPV阳性。其中HPV-56型和HPV-51型最常见，分别占32.3%和31.4%。HPV-53(20.5%)、HPV-18(18.5%)、HPV-58(17.6%)、HPV-52(16.0%)和HPV-16.6%)是其他最常见的检测类型。这些频率在研究人群中的患病率分别为2.35%、2.12%、2.02%、1.84%和1.80%。对于低风险hpv，在12.9%的样本中检测到HPV-6。较少见的类型(3%)为:HPV-70、HPV-11和HPV-26。结论HPV-56、HPV-51、HPV-53、HPV-18、HPV-58、HPV-52和HPV-16的检出率呈下降趋势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Papillomavirus Research VIROLOGY-

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.