Circulating tumor cells in oral squamous cell carcinoma – Current status of its usefulness in clinical practice

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Geetha Rajalakshmi, K. Pavithran, N. Smitha, S. Iyer
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引用次数: 1

Abstract

Circulating tumor cells (CTCs) are considered metastatic intermediates that are being shed from the primary tumor which extravasate and circulate in the blood. CTCs are a hotspot of oncological research for the last few decades. It has immense potential in early diagnosis, detecting recurrence, determining chemotherapeutic efficiency as well as individuals' sensitivity toward drugs. CTCs are emerging as an invaluable detection tool in bridging the gap in the transition from a population-based to a personalized approach. These cells may be a future target in refining and personalizing cancer treatment. This review attempts to critically analyze the current understanding of CTCs in oral squamous cell carcinoma and the challenges to its clinical utility at present.
口腔鳞状细胞癌循环肿瘤细胞的临床应用现状
循环肿瘤细胞(CTC)被认为是从原发性肿瘤脱落的转移中间体,其外渗并在血液中循环。CTC是近几十年肿瘤学研究的热点。它在早期诊断、检测复发、确定化疗效率以及个人对药物的敏感性方面具有巨大的潜力。CTC正在成为一种宝贵的检测工具,可以弥补从基于人群的方法向个性化方法过渡的差距。这些细胞可能是癌症治疗的精细化和个性化的未来目标。这篇综述试图批判性地分析目前对口腔鳞状细胞癌CTC的理解以及目前对其临床应用的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Head & Neck Physicians and Surgeons
Journal of Head & Neck Physicians and Surgeons MEDICINE, GENERAL & INTERNAL-
CiteScore
0.30
自引率
0.00%
发文量
0
审稿时长
15 weeks
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