Structural biology of SARS-CoV-1/SARS-CoV-2 main protease

IF 2 2区化学 Q2 CRYSTALLOGRAPHY

Crystallography Reviews Pub Date : 2023-04-03 DOI:10.1080/0889311X.2023.2222275

Yunyun Gao, J. Kaub, G. Santoni, N. Pearce, A. Thorn

引用次数: 0

Abstract

The SARS-CoV-1/SARS-CoV-2 main protease cleaves the nascent viral polyproteins into biologically functional molecules, which are essential for viral reproduction inside the host cell. With more than 500 crystal structures available, it is one of the most heavily researched coronavirus proteins and a popular drug target. This review focuses on putting the function and structure of the main protease into a historical perspective, highlighting the structure-based design of inhibitors of the main protease and discussing potential future research directions.

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SARS-CoV-1/SARS-CoV-2主要蛋白酶的结构生物学

严重急性呼吸系统综合征冠状病毒1/严重急性呼吸综合征冠状病毒2型主要蛋白酶将新生的病毒多蛋白切割成生物功能分子，这些分子对病毒在宿主细胞内繁殖至关重要。它有500多种晶体结构，是研究最深入的冠状病毒蛋白之一，也是一种流行的药物靶点。这篇综述的重点是将主要蛋白酶的功能和结构放在历史的角度来看，重点介绍了主要蛋白酶抑制剂的基于结构的设计，并讨论了未来潜在的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Crystallography Reviews CRYSTALLOGRAPHY-

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Crystallography Reviews publishes English language reviews on topics in crystallography and crystal growth, covering all theoretical and applied aspects of biological, chemical, industrial, mineralogical and physical crystallography. The intended readership is the crystallographic community at large, as well as scientists working in related fields of interest. It is hoped that the articles will be accessible to all these, and not just specialists in each topic. Full reviews are typically 20 to 80 journal pages long with hundreds of references and the journal also welcomes shorter topical, book, historical, evaluation, biographical, data and key issues reviews.