Accelerated hypofractionated radiotherapy for chest wall and nodal irradiation using hybrid techniques

IF 0.3 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Radiotherapy in Practice Pub Date : 2021-12-13 DOI:10.1017/S1460396921000601

K. Balaji, V. Ramasubramanian

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引用次数: 0

Abstract

Abstract Aim: This study compares three different hybrid plans, for left-sided chest wall (CW) and nodal stations irradiation using a hypofractionated dose regimen. Materials and methods: Planning target volumes (PTVs) of 25 breast cancer patients that included CW, supraclavicular (SCL) and internal mammary node (IMN) were planned with 3 different hybrid techniques: 3DCRT+IMRT, 3DCRT+VMAT and IMRT+VMAT. All hybrid plans were generated with a hypofractionated dose prescription of 40·5 Gy in 15 fractions. Seventy per cent of the dose was planned with the base-dose component and remaining 30% of the dose was planned with the hybrid component. All plans were evaluated based on the PTVs and organs at risk (OARs) dosimetric parameters. Results: The results for PTVs parameters have shown that the 3DCRT+IMRT and 3DCRT+VMAT plans were superior in uniformity index to the IMRT+VMAT plan. The OARs dose parameters were comparable between hybrid plans. The IMRT+VMAT plan provided a larger low dose volume spread to the heart and ipsilateral lung (p < 0·001). The 3DCRT+VMAT plan required less monitor units and treatment time (p = 0·005) than other plans. Conclusion: The 3DCRT+VMAT hybrid plan showed superior results with efficient treatment delivery and provide clinical benefit by reducing both low and high dose levels.

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采用混合技术对胸壁和淋巴结进行加速低分割放疗

摘要目的：本研究比较了三种不同的混合方案，即使用低分割剂量方案的左侧胸壁（CW）和淋巴结站照射。材料与方法：采用3DCRT+IMRT、3DCRT+VMAT和IMRT+VMAT三种不同的混合技术，对25例癌症患者的计划靶体积（PTV）进行了规划，包括CW、锁骨上（SCL）和内乳结（IMN）。所有的混合计划都是用15个部分的40.5Gy的低分割剂量处方生成的。70%的剂量是用基本剂量成分计划的，剩下的30%是用混合成分计划的。所有计划都是根据PTV和危险器官（OARs）剂量测定参数进行评估的。结果：PTV参数结果表明，3DCRT+IMRT和3DCRT+AMMAT方案在均匀性指数上优于IMRT+VMAT方案。混合方案之间的OARs剂量参数具有可比性。IMRT+VMAT方案向心脏和同侧肺提供了更大的低剂量体积扩散（p＜0.001）。3DCRT+VMAT方案比其他方案需要更少的监测单元和治疗时间（p=0.005）。结论：3DCRT+VMAT混合方案显示出良好的疗效和有效的治疗效果，并通过降低低剂量和高剂量水平提供了临床效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radiotherapy in Practice RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Journal of Radiotherapy in Practice is a peer-reviewed journal covering all of the current modalities specific to clinical oncology and radiotherapy. The journal aims to publish research from a wide range of styles and encourage debate and the exchange of information and opinion from within the field of radiotherapy practice and clinical oncology. The journal also aims to encourage technical evaluations and case studies as well as equipment reviews that will be of interest to an international radiotherapy audience.