Quality of life in people with Type 2 diabetes; a study in a multi-ethnic clinical trial population

IF 0.4 Q4 ENDOCRINOLOGY & METABOLISM
Shaifali Kulkarni, P. Welsh, Myzoon Ali, J. Petrie
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Abstract

Background: The long-term burden of self-management in type 2 diabetes can impact quality of life. Aims: To examine associations between demographic and clinical factors, anxiety/depression and perception of health in people with type 2 diabetes. Methods: Retrospective analyses of anonymised data from completed clinical trials provided by the diabetes subsection of Virtual International Cardiovascular and Cognitive Trials Archive (VICCTA). Data on demographics, polypharmacy, HbA1c, anxiety/depression (EQ-5D-3L) and perception of health (EQ-5D-3L VAS) were extracted. Regression analyses explored associations amongst polypharmacy, HbA1c and quality of life (anxiety/depression and health perception) at baseline. Results: In 2783 participants with type 2 diabetes (median age 66 years (IQR 61–70), n=1,595 (57%) male), female sex and Caucasian/European ethnicity were each associated with increased anxiety/depression and lower EQ-5D-3L VAS scores. Following adjustment for covariates, each additional prescribed medication was associated with increased anxiety/depression: OR 1.09 (95% CI 1.04 to 1.14; p<0.001) and lower VAS scores: B= −1.06 (95% CI −1.37 to −0.75, p<0.001)). Conclusion: Demographic factors and polypharmacy are associated with anxiety/depression and lower health perception.
2型糖尿病患者的生活质量;一项多民族临床试验人群的研究
背景:2型糖尿病患者自我管理的长期负担会影响生活质量。目的:研究2型糖尿病患者的人口统计学和临床因素、焦虑/抑郁和健康感知之间的关系。方法:对虚拟国际心血管和认知试验档案(VICCTA)糖尿病分部提供的已完成临床试验的匿名数据进行回顾性分析。提取了人口统计学、多药治疗、HbA1c、焦虑/抑郁(EQ-5D-3L)和健康感知(EQ-5D-3L VAS)的数据。回归分析探讨了基线时多药治疗、HbA1c和生活质量(焦虑/抑郁和健康感知)之间的关系。结果:在2783名患有2型糖尿病的参与者中(中位年龄66岁(IQR 61-70),n=1595(57%)男性),女性和高加索/欧洲种族均与焦虑/抑郁增加和EQ-5D-3L VAS评分降低有关。在校正协变量后,每增加一种处方药都与焦虑/抑郁增加相关:OR 1.09(95%CI 1.04至1.14;p<0.001)和VAS评分降低:B=−1.06(95%CI−1.37至−0.75,p<0.001)。结论:人口统计学因素和多药治疗与焦虑/抑郁症和健康感知降低有关。
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来源期刊
British Journal of Diabetes
British Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
16.70%
发文量
15
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