Inviting regulatory T cells to pregnant endometrium: friends or foes in adverse pregnancy outcomes?

S. Cheng, Zhengke Wang, Surendra Sharma
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引用次数: 0

Abstract

Among decidual immune cells, regulatory T cells (Tregs) have been unanimously recognized as central contributors to tolerance and maintenance of healthy pregnancy. Numerical and functional downregulation of Tregs or disturbed interaction of Tregs with trophoblasts and other immune cells have been linked to early pregnancy loss such as idiopathic infertility and miscarriage and later-onset adverse pregnancy outcomes including preeclampsia. This review focuses on the mechanisms for regulating the generation, expansion, and function of Tregs, the roles of Tregs in maintaining maternal immune tolerance through crosstalk with trophoblasts and other decidual regulatory immune cells, and how Tregs may play foes to pregnancy and contribute to the programming of pregnancy-related complications. Therapeutic options for implantation failure and adverse pregnancy outcomes are now part of the emerging significance of Tregs in pregnancy tolerance and maintenance.
诱导调节性T细胞进入妊娠子宫内膜:不良妊娠结局的朋友还是敌人?
在个体免疫细胞中,调节性T细胞(Tregs)被一致认为是耐受和维持健康妊娠的核心贡献者。Tregs的数量和功能下调或Tregs与滋养细胞和其他免疫细胞的相互作用紊乱与早期妊娠丢失(如特发性不孕症和流产)以及迟发性不良妊娠结局(包括先兆子痫)有关。本文综述了Tregs的产生、扩增和功能调控机制,Tregs通过与滋养细胞和其他个体调节性免疫细胞的串扰在维持母体免疫耐受中的作用,以及Tregs如何成为妊娠的敌人并参与妊娠相关并发症的编程。植入失败和不良妊娠结局的治疗选择现在是Tregs在妊娠耐受性和维持中的新意义的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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