Hypotensive therapy effectiveness evaluation in primary open-angle glaucoma evidenced by pattern electroretinogram data

Q4 Medicine
E. Tur, T. Y. Kozhevnikova
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引用次数: 0

Abstract

Purpose. To evaluate the change in the functional activity of retinal ganglion cells (RGCs) in response to intraocular pressure (IOP) drop in patients with newly diagnosed early stage primary open-angle glaucoma (POAG) using a pattern electroretinogram (PERG). Material and methods. A prospective non-randomized cohort study included 12 patients (24 eyes) including 5 men, 7 women, aged 63.42 ± 2.96 years with newly diagnosed early stage POAG in at least one eye, who underwent PERG (Diopsys Nova, Diopsys, Inc.) in addition to an ophthalmologic examination. After being diagnosed with POAG, all patients were prescribed prostaglandin analogues as monotherapy. One and four months into the treatment, repeated examinations took place. Results. At these time points, a significant decrease in IOP was noted, accompanied by an increase in PERG parameters , which indicates an improvement in the functional activity of RGCs, yet no linear relationship between the IOP decrease and the improvement in PERG parameters could be found. Conclusion. Early stage naïve-treatment POAG patients with minimally impaired visual fields as determined by threshold computer perimetry may have their RGCs functional activity partially restored and IOP lessened thanks to continuous IOP-lowering therapy with prostaglandin analogues. PERG can be used as a method for evaluating the effectiveness of glaucoma hypotensive therapy in terms of maintaining and improving the functional activity of RGCs.
视网膜电图显示原发性开角型青光眼降压治疗效果评价
目的。应用视网膜电图(PERG)评价新诊断的早期原发性开角型青光眼(POAG)患者眼压(IOP)下降时视网膜神经节细胞(rgc)功能活性的变化。材料和方法。一项前瞻性非随机队列研究纳入12例(24只眼)患者,其中男5例,女7例,年龄63.42±2.96岁,新诊断为至少一只眼早期POAG,除眼科检查外,接受PERG (Diopsys Nova, Diopsys, Inc.)。确诊POAG后,所有患者均给予前列腺素类似物单药治疗。治疗1个月和4个月后,进行了重复检查。结果。在这些时间点,IOP明显下降,PERG参数升高,表明rgc功能活性有所改善,但IOP下降与PERG参数改善之间没有线性关系。结论。早期naïve-treatment POAG患者通过阈值计算机视野检查发现视野最小损害,由于前列腺素类似物的持续降眼压治疗,他们的RGCs功能活动部分恢复,眼压降低。PERG可作为评价青光眼降压治疗在维持和改善rgc功能活性方面有效性的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
107
审稿时长
16 weeks
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