The Prognostic Importance of the Systemic Immune-inflammation Index in Patients with Crimean-Congo Hemorrhagic Fever

Abstract

Aim: To evaluate the power of the systemic immune-inflammation index (SII) in the prediction of mortality in patients with Crimean-Congo hemorrhagic fever (CCHF) presenting at the emergency department (ED). Materials and Methods: The study included patients who presented at the ED between April 2020 and November 2022 and were hospitalized for treatment in the Infectious Diseases Department. The demographic data, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and SII were recorded. Categorical data were analyzed with the chi-square test and continuous data with the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was performed to determine the factors predicting the risk of mortality. Results: The SII value (p=0.010) and NLR (p<0.001) were determined to be significantly higher and the PLR (p=0.015) was significantly lower in CCHF patients who developed mortality compared to those who did not. ROC analysis showed the NLR and SII parameters to be significant in the prediction of mortality. Conclusion: SII at the time of presentation at the ED can be used for predicting the mortality in CCHF patients.