MRI evaluation of myelopathic pain after spinal cord injury or spinal cord tumor surgery

Pain Research Pub Date : 2020-03-31 DOI:10.11154/pain.35.34

Osahiko Tsuji, Kohei Matsubayashi, Yosuke Horiuchi, Yuji Komaki, J. Hata, Tsunehiko Konomi, K. Fujiyoshi, Shizuko Kosugi, M. Nakamura

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Abstract

Patients with spinal cord injury suffered from not only motor paralysis but also intolerable neuropathic pain. Regarding the mechanism, various theories such as functional changes in the brain, disorders within the spinal dorsal horn and/or spinothalamic tract have been proposed. However, the feasible animal models with solid reproducibility has been insufficiently verified. We have established the mice fMRI system, reported the results of mice–fMRI after L 5 nerve injury and resting state–fMRI imaging after thoracic cord transection injury in mice. Furthermore, in a clinical setting we evaluated the brain morphometry of the cases with spinal intra medullary tumor surgery by VBM, and found the gray matter volume of some brain regions was increased related with pain intensity. Besides fMRI and VBM analysis, we developed diffusion MRI techniques which could depict neuronal axons and myelination within the spinal cord (“diffusion tensor tractgraphy” and “myelin map”, respectively). In this review, I would like to outline our results of MRI analysis of neuropathic pain so far.

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脊髓损伤或脊髓肿瘤手术后脊髓性疼痛的MRI评价

脊髓损伤患者不仅遭受运动麻痹，还遭受难以忍受的神经性疼痛。关于机制，已经提出了各种理论，如大脑的功能变化、脊髓背角和/或棘丘脑束内的疾病。然而，具有固体再现性的可行动物模型尚未得到充分验证。我们建立了小鼠功能磁共振成像系统，报道了小鼠L5神经损伤后的功能磁共振和小鼠胸脊髓横断损伤后的静息状态功能磁共振的成像结果。此外，在临床环境中，我们通过VBM评估了脊髓髓内肿瘤手术病例的大脑形态计量学，发现一些大脑区域的灰质体积随着疼痛强度的增加而增加。除了fMRI和VBM分析外，我们还开发了扩散MRI技术，可以描述脊髓内的神经元轴突和髓鞘形成（分别为“扩散张量束描记术”和“髓鞘图”）。在这篇综述中，我想概述我们迄今为止对神经性疼痛的MRI分析结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pain Research CLINICAL NEUROLOGY-

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