Synthesis of non-ionic surfactants nano-vesicles for clarithromycin oral delivery

IF 1.2 4区工程技术 Q4 CHEMISTRY, APPLIED

Tenside Surfactants Detergents Pub Date : 2023-06-14 DOI:10.1515/tsd-2022-2476

I. Ali, Sarzamin Khan, Samrein Ahmed, Serab Khan, H. Ali, Raiz Ullah Shafiullah, M. Shah, Z. A. Shah

{"title":"Synthesis of non-ionic surfactants nano-vesicles for clarithromycin oral delivery","authors":"I. Ali, Sarzamin Khan, Samrein Ahmed, Serab Khan, H. Ali, Raiz Ullah Shafiullah, M. Shah, Z. A. Shah","doi":"10.1515/tsd-2022-2476","DOIUrl":null,"url":null,"abstract":"Abstract In order to improve the solubility and bioavailability of poorly water-soluble drugs, the synthesis of cost-effective nonionic surfactants has been the subject of greater scientific interest. The present study focuses on the synthesis of sulfonyl chloride derivatives as nonionic surfactants (surfactant 1 and surfactant 2) and their evaluation for the preparation of a clarithromycin-loaded niosomal drug delivery system. Surfactants 1 and 2 were characterised by EI-MS and 1H NMR spectroscopy. The shape and size of the drug-loaded niosomal vesicles from the synthesised surfactants were examined by atomic force microscopy (AFM) and revealed a round morphology with an average size of (230.8 ± 2.35) nm and (248.1 ± 2.54) nm for the vesicles of surfactant 1 and surfactant 2, respectively. The zeta potential of surfactant 1-based niosomal vesicles was (– 7.70 ± 1.00) mV and that of surfactant 2 was (−14.6 ± 1.08) mV. The lower zeta potential values for surfactant 1 and surfactant 2-based niosomal vesicles showed that these vesicles were neutral and relatively stable. The vesicles of surfactant 1 and 2 have a capacity to entrap the drug of about (62 ± 2.26) % and (69.67 ± 3.23) %, respectively. The vesicles of surfactant 1 released the largest amount of drug, i.e. (70.00 ± 2.45) % at pH 1.2. Biocompatibility in human blood and toxic effects on various cell lines were also studied for surfactants 1 and 2, and they were found to be biocompatible and non-cytotoxic.","PeriodicalId":22258,"journal":{"name":"Tenside Surfactants Detergents","volume":"60 1","pages":"328 - 337"},"PeriodicalIF":1.2000,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tenside Surfactants Detergents","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/tsd-2022-2476","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract In order to improve the solubility and bioavailability of poorly water-soluble drugs, the synthesis of cost-effective nonionic surfactants has been the subject of greater scientific interest. The present study focuses on the synthesis of sulfonyl chloride derivatives as nonionic surfactants (surfactant 1 and surfactant 2) and their evaluation for the preparation of a clarithromycin-loaded niosomal drug delivery system. Surfactants 1 and 2 were characterised by EI-MS and 1H NMR spectroscopy. The shape and size of the drug-loaded niosomal vesicles from the synthesised surfactants were examined by atomic force microscopy (AFM) and revealed a round morphology with an average size of (230.8 ± 2.35) nm and (248.1 ± 2.54) nm for the vesicles of surfactant 1 and surfactant 2, respectively. The zeta potential of surfactant 1-based niosomal vesicles was (– 7.70 ± 1.00) mV and that of surfactant 2 was (−14.6 ± 1.08) mV. The lower zeta potential values for surfactant 1 and surfactant 2-based niosomal vesicles showed that these vesicles were neutral and relatively stable. The vesicles of surfactant 1 and 2 have a capacity to entrap the drug of about (62 ± 2.26) % and (69.67 ± 3.23) %, respectively. The vesicles of surfactant 1 released the largest amount of drug, i.e. (70.00 ± 2.45) % at pH 1.2. Biocompatibility in human blood and toxic effects on various cell lines were also studied for surfactants 1 and 2, and they were found to be biocompatible and non-cytotoxic.

查看原文本刊更多论文

口服克拉霉素非离子表面活性剂纳米囊泡的合成

摘要为了提高水溶性差的药物的溶解度和生物利用度，合成具有成本效益的非离子表面活性剂一直是科学界关注的课题。本研究的重点是作为非离子表面活性剂的磺酰氯衍生物（表面活性剂1和表面活性剂2）的合成及其在制备克拉霉素负载的羊膜给药系统中的评价。表面活性剂1和2通过EI-MS和1H NMR光谱进行表征。通过原子力显微镜（AFM）检查了合成的表面活性剂负载药物的囊泡的形状和大小，发现表面活性剂1和表面活性剂2的囊泡具有圆形形态，平均大小分别为（230.8±2.35）nm和（248.1±2.54）nm。表面活性剂1和表面活性剂2的ζ电位分别为（–7.70±1.00）mV和（−14.6±1.08）mV。表面活性剂和表面活性素2的较低ζ电位值表明这些囊泡是中性且相对稳定的。表面活性剂1和2的囊泡对药物的截留率分别为（62±2.26）%和（69.67±3.23）%。表面活性剂1的囊泡在pH 1.2时释放出最大量的药物，即（70.00±2.45）%。还研究了表面活性剂1和2在人体血液中的生物相容性以及对各种细胞系的毒性作用，发现它们具有生物相容性和非细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Tenside Surfactants Detergents 工程技术-工程：化工

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

3.8 months

期刊介绍： Tenside Surfactants Detergents offers the most recent results of research and development in all fields of surfactant chemistry, such as: synthesis, analysis, physicochemical properties, new types of surfactants, progress in production processes, application-related problems and environmental behavior. Since 1964 Tenside Surfactants Detergents offers strictly peer-reviewed, high-quality articles by renowned specialists around the world.