Gabapentin completely neutralized the acute morphine activation in the rat hypothalamus: a c-Fos study

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2019-05-01 DOI:10.2217/FNL-2018-0037

J. Kazi, Rasdi Zatilfarihiah

引用次数: 1

Abstract

Aim: The molecular mechanism of gabapentin (GBP)–morphine combinational function and its neuro-anatomical sites of action to prevent, to neutralize morphine side effects and also the enhancement its analgesic effect of morphine is unknown. Methods: Morphine (10 mg/kg), saline, co-injection: GBP (150 mg/kg) with morphine (10 mg/kg) were injected by intraperitoneal injection in rats under deep anaesthesia. C-Fos immunohistochemistry technique was used to locate c-Fos expression in rat hypothalamus. Results: Gabapentin in combination with morphine significantly (p < 0.01) attenuated the acute morphine induced c-Fos immunoreactive neuron in hypothalamus. Conclusion: GBP neutralized the morphine sensitization in rat hypothalamus. GBP might neuromodulate and or antagonize the receptor regulatory machinery of morphine sensitization circuit which might work for drug discovery of morphine abuse.

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加巴喷丁完全中和大鼠下丘脑急性吗啡激活:一项c-Fos研究

目的：加巴喷丁（GBP）-吗啡联合作用的分子机制及其预防、中和吗啡副作用和增强吗啡镇痛作用的神经解剖学部位尚不清楚。方法：在深度麻醉下，大鼠腹腔注射吗啡（10mg/kg）、生理盐水、GBP（150mg/kg）和吗啡（10mgg/kg）。应用C-Fos免疫组化技术定位大鼠下丘脑C-Fos的表达。结果：加巴喷丁联合吗啡对吗啡诱导的急性下丘脑c-Fos免疫反应神经元有明显的减毒作用（p<0.01）。结论：GBP可中和大鼠下丘脑吗啡致敏作用。GBP可能神经调节和/或拮抗吗啡致敏回路的受体调节机制，这可能有助于发现吗啡滥用的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.