Expression of HER-2 in colorectal cancer and its relationship with clinicopathological features and prognosis

中华普通外科杂志 Pub Date : 2019-12-25 DOI:10.3760/CMA.J.ISSN.1007-631X.2019.12.013

Wulin Wu, Zejian Lyu, Zifeng Yang, Q. Yan, Yuwen Luo, W. Liang, Deqing Wu, Weixian Hu, Guanfu Cai, Xue-qing Yao, Yong Li

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Abstract

Objective To investigate the correlation between the expression of (epidermal growth factor receptor-2, HER-2) and clinicopathological features and survival of colorectal cancer. Methods From Jan 2005 to Dec 2015, all colorectal cancer cases were enrolled that the expression levels of HER-2 were detected in Guangdong Provincial People′s Hospital. Clinicopathological features of the tumors and survival of the patients were analyzed . Results A total of 1 463 cases were collected in 10 years, including 711 cases (48.6%) of HER-2 (-), 470 cases (32.1%) of HER-2 (+ ), 249 cases (17%) of HER-2 (+ + ), and 33 cases (2.3%) of HER-2 (+ + + ). Correlation analysis shows that the expression levels of HER-2 were significantly correlated with tumor differentiation and the depth of tumor invasion(T stage), but not correlated with gender, age, tumor location, N stage, M stage, TNM stage and overall survival, and disease-free survival. Conclusion The expression of HER-2 may be related to tumor differentiation and growth infiltration, but it cannot be used as a predictor of prognosis in patients with colorectal cancer. Key words: Colorectal neoplasms; Receptor, epidermal growth factor; Pathology, clinical; Prognosis

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HER-2在结直肠癌中的表达及其与临床病理特征及预后的关系

目的探讨(表皮生长因子受体-2,HER-2)表达与结直肠癌临床病理特征及生存的关系。方法选取2005年1月至2015年12月在广东省人民医院进行HER-2表达检测的结直肠癌患者。分析肿瘤的临床病理特征及患者的生存情况。结果10年共收集到1 463例，其中HER-2(-)型711例(48.6%)，HER-2(+)型470例(32.1%)，HER-2(+ +)型249例(17%)，HER-2(+ + +)型33例(2.3%)。相关分析显示HER-2表达水平与肿瘤分化及肿瘤侵袭深度(T期)有显著相关性，与性别、年龄、肿瘤部位、N期、M期、TNM期及总生存期、无病生存期无相关性。结论HER-2的表达可能与肿瘤分化和生长浸润有关，但不能作为预测结直肠癌患者预后的指标。关键词:结直肠肿瘤;受体，表皮生长因子;病理、临床;预后

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中华普通外科杂志

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