Development of Garlic Oral Beads using Garlic Nanoparticles and Studies on their Protective Effects Against Avian Coccidiosis

Pub Date : 2021-10-15 DOI:10.1142/s1793984421500070

Viswanathan Kaliyaperumal, A. Palavesam, Arul kumar Kandasamy, Vijayashanthi Ramalingam, Chitra Karuppan, Madhan Nithiyanantham, Indira Harikrishnan, D. Gopal, R. Muthusamy, S. Alagesan

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Abstract

In this paper, new oral beads were developed for poultry applications using garlic nanoparticles (NPs). The NPs were synthesized using water in oil micro-emulsion method and it was confirmed using energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. The biocompatibility was evaluated by using the chicken blood, chicken intestinal cell line and the results indicated that the particles are highly safe. The oral beads were formulated using hydroxyl propyl methyl cellulose phthalate as polymer protective layer and specifically dissolved in pH 6.5 and released the NPs at the intestine. To study their impacts, the chickens were fed with beads starting day 3 after hatching, and their weight was recorded. To study the anti-parasitic effect, the chickens were challenged with Eimeria species. The active treatments with oral beads effectively cure the intestinal damages triggered by the Eimeria species and improved the chicken weight. The prophylactic treatment 100% protects chicken against Eimeria infection and increased the body weight.

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大蒜纳米粒口服微珠的研制及其对鸡球虫病的保护作用研究

本文利用大蒜纳米颗粒(NPs)开发了家禽用口服微球。采用油包水微乳液法合成了NPs，并用能量色散x射线光谱(EDX)、傅里叶红外光谱(FTIR)和拉曼光谱对其进行了验证。用鸡血、鸡肠细胞系进行了生物相容性评价，结果表明该颗粒具有较高的安全性。口服微球以邻苯二甲酸羟丙基甲基纤维素为聚合物保护层，在pH 6.5下特异性溶解，并在肠道释放NPs。为研究其对雏鸡的影响，在雏鸡孵化后第3天开始饲喂微珠，并记录其体重。为了研究艾美耳球虫对鸡的抗寄生作用。口服小丸积极治疗能有效治愈艾美耳球虫引起的肠道损伤，提高鸡的体重。预防处理100%保护鸡不受艾美耳球虫感染，增加体重。

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