Research progress of non-coding RNA in hepatic ischemia-reperfusion injury

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2020-01-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2020.01.019

Shilong Zhang, Zanjie Feng, Cijun Peng, Weidong Gao, Yuling Duan, Guoxin Fan

引用次数: 0

Abstract

Hepatic ischemia-reperfusion injury (HIRI) is the main cause of liver damage and even multiple organ failure after complex liver surgery. When liver ischemia reperfusion occurs, the non-coding RNAs in the liver tissue is dysregulated and part of the non-coding RNAs with abnormal expression is involved in HIRI regulation. Non-coding RNAs to may be the intervention target for reducing HIRI. This article summarized the types and related functions of non-coding RNAs, the role of different non-coding RNAs in HIRI, and the interconnections between various non-coding RNAs in HIRI. Key words: Reperfusion injury; Liver; Non-coding RNA; MicroRNA; Small interfering RNA

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非编码RNA在肝缺血再灌注损伤中的研究进展

肝缺血再灌注损伤(HIRI)是复杂肝脏手术后肝脏损害甚至多器官功能衰竭的主要原因。肝脏缺血再灌注时，肝组织内的非编码rna发生失调，部分表达异常的非编码rna参与HIRI调控。非编码rna可能是减少HIRI的干预靶点。本文综述了非编码rna的种类和相关功能，不同非编码rna在HIRI中的作用，以及各种非编码rna在HIRI中的相互联系。关键词:再灌注损伤;肝;非编码RNA;微rna;小干扰RNA

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.