The Role of Genetics in a Personalized Approach in Patients with Feeding Problems, Overweight and Obesity

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2022-04-01 DOI:10.2478/amb-2022-0003

O. Antonova, V. Spasova

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引用次数: 0

Abstract

Abstract Aim: For the last 20 years a large amount of data was gathered showing a genetic predisposition to overweight and obesity. The aim of this study was to demonstrate a personalized, genetic-based approach in normalizing the patients’ weight and eating habits. Materials and methods: Eight patients – seven women and one man – aged 28-51 years with BMI ranging from 17,58 to 38,95 kg/m2 were examined. Two of them were underweight, two – with normal weight, two – overweight, and two – obese. Patients were genotyped for: APOA2 (rs5082), ADIPOQ, (rs17300539), FTO (rs9939609), KCTD10 (rs10850219), LIPC (rs1800588), MMAB (rs2241201), PPARG (rs1801282), ANKK1/DRD2 (rs1800497), TAS2R38 (rs1726866), LEPR (rs2025804) and SLC2A2 (rs5400). Based on the genetic results, the type of diet (balanced, Mediterranean, low-fat and low-carbohydrate) was determined; the predisposition to unhealthy eating habits was described and followed by a genetic counseling to clarify the findings as well as a dietitian consultation to formulate a personalized diet. Results: Our results showed that the patients’ actual diet was equivocally different from the genetically determined one. Аll patients, except for one, had hereditary predispositions to a particular unhealthy eating habit. Conclusion: The inclusion of genetic testing and personalization of the diet facilitates the long-term maintenance of optimal body weight.

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遗传学在喂养问题、超重和肥胖患者个性化治疗中的作用

摘要目的：在过去的20年里，收集了大量数据，显示超重和肥胖的遗传易感性。这项研究的目的是展示一种个性化的、基于基因的方法来规范患者的体重和饮食习惯。材料和方法：8名患者——7名女性和1名男性——年龄28-51岁，BMI范围为17,58至38,95 kg/m2。其中两人体重不足，两人体重正常，两人超重，两人肥胖。对患者进行基因分型：APOA2（rs5082）、ADIPOQ（rs17300539）、FTO（rs9939609）、KCTD10（rs10850219）、LIPC（rs1800588）、MMAB（rs2241201）、PPARG（rs1801282）、ANKK1/DRD2（rs1800497）、TAS2R38（rs1726866）、LEPR（rs2025804）和SLC2A2（rs5400）。根据遗传结果，确定了饮食类型（均衡、地中海、低脂和低碳水化合物）；描述了不健康饮食习惯的倾向，随后进行了基因咨询以澄清研究结果，并咨询了营养师以制定个性化饮食。结果：我们的研究结果表明，患者的实际饮食与基因决定的饮食有着明显的不同。除一名患者外，所有患者都有特定不健康饮食习惯的遗传倾向。结论：纳入基因检测和个性化饮食有助于长期保持最佳体重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.