Impact of Estradiol Supplementation during Luteal Phase Support on the In vitro Fertilization Clinical Outcome: Systematic Review and Meta-Analysis

Abstract

This study aimed to clarify whether estradiol (E2) supplementation as luteal phase support (LPS) has benefit effect on the clinical outcomes after IVF/ICSI. A meta-analysis was conducted. E2+P group had significant higher CPR and ongoing PR than that of P-only group. GnRH-a protocol group had a significant higher CPR and ongoing PR with E2+P, whereas GnRH-ant protocol group had no difference in CPR, ongoing PR, IR, and AR among E2+P and Ponly groups. So, E2 supplementation as LPS has beneficial effect on the clinical outcomes only during cycles with GnRH-a protocol. Background