Probiotics in Crohn's disease remission: a systematic review

IF 0.5 4区医学 Q4 NUTRITION & DIETETICS

Archivos Latinoamericanos De Nutricion Pub Date : 2022-04-30 DOI:10.37527/2022.72.1.006

Kamilla Pontes Azevedo, Maria Zilda de Jesus Catulio, Rávila Graziany Machado de Souza, Maria Luiza Ferreira Stringhini

{"title":"Probiotics in Crohn's disease remission: a systematic review","authors":"Kamilla Pontes Azevedo, Maria Zilda de Jesus Catulio, Rávila Graziany Machado de Souza, Maria Luiza Ferreira Stringhini","doi":"10.37527/2022.72.1.006","DOIUrl":null,"url":null,"abstract":"Crohn's disease (CD) is an inflammatory condition that can affect the entire gastrointestinal tract due to an exacerbated and inadequate immune system response. Objective. This study aimed to conduct a systematic review, through clinical trials, about the use of probiotics in humans with CD. Materials and methods. Research was carried out in the PubMed, Scopus and Science Direct databases using the keywords “Crohn's disease” and “probiotics”. We conducted the review by searching clinical trials published from 2000 to December 2019. Results. Of 2,164 articles found, only nine were considered eligible for this review. The studies investigated patients with CD at different stages of the pathology, and in three studies the potential effect of probiotics in the active phase was observed; in two, in the remission phase; and in four, after intestinal surgery. The sample size of the studies ranged from 11 to 165 individuals and the age of the participants between 5 and 71 years. Gram-positive bacteria were used in six clinical interventions and in two studies yeasts were used. As for the significant results obtained with the treatment with probiotics, in one study there was beneficial clinical effects in patients and, in another, there was an improvement in intestinal permeability. Conclusion. Currently, it is not possible to establish a recommendation for probiotic therapy to control CD due to the few clinical trials with significant results. There is a need for more research on clinical intervention with probiotics in CD to clarify the action, define doses and time of use.","PeriodicalId":8390,"journal":{"name":"Archivos Latinoamericanos De Nutricion","volume":" ","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos Latinoamericanos De Nutricion","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.37527/2022.72.1.006","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 1

Abstract

Crohn's disease (CD) is an inflammatory condition that can affect the entire gastrointestinal tract due to an exacerbated and inadequate immune system response. Objective. This study aimed to conduct a systematic review, through clinical trials, about the use of probiotics in humans with CD. Materials and methods. Research was carried out in the PubMed, Scopus and Science Direct databases using the keywords “Crohn's disease” and “probiotics”. We conducted the review by searching clinical trials published from 2000 to December 2019. Results. Of 2,164 articles found, only nine were considered eligible for this review. The studies investigated patients with CD at different stages of the pathology, and in three studies the potential effect of probiotics in the active phase was observed; in two, in the remission phase; and in four, after intestinal surgery. The sample size of the studies ranged from 11 to 165 individuals and the age of the participants between 5 and 71 years. Gram-positive bacteria were used in six clinical interventions and in two studies yeasts were used. As for the significant results obtained with the treatment with probiotics, in one study there was beneficial clinical effects in patients and, in another, there was an improvement in intestinal permeability. Conclusion. Currently, it is not possible to establish a recommendation for probiotic therapy to control CD due to the few clinical trials with significant results. There is a need for more research on clinical intervention with probiotics in CD to clarify the action, define doses and time of use.

查看原文本刊更多论文

益生菌在克罗恩病缓解中的应用:一项系统综述

克罗恩病(CD)是一种炎症性疾病，由于免疫系统反应加剧和不足，可影响整个胃肠道。目标。本研究旨在通过临床试验，对益生菌在乳糜泻患者中的应用进行系统综述。研究在PubMed、Scopus和Science Direct数据库中进行，关键词是“克罗恩病”和“益生菌”。我们通过检索2000年至2019年12月发表的临床试验进行了综述。结果。在发现的2164篇文章中，只有9篇被认为符合本综述的条件。这些研究调查了不同病理阶段的乳糜泻患者，其中三项研究观察了益生菌在活跃期的潜在作用;二是在缓解期;四组是在肠道手术后。这些研究的样本量从11到165人不等，参与者的年龄在5到71岁之间。革兰氏阳性菌在六项临床干预中使用，在两项研究中使用酵母。至于用益生菌治疗所取得的显著结果，一项研究对患者有有益的临床效果，另一项研究对肠道通透性有改善。结论。目前，由于具有显著结果的临床试验很少，因此不可能推荐益生菌治疗来控制乳糜泻。益生菌对乳糜泻的临床干预需要更多的研究，以明确作用，确定剂量和使用时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archivos Latinoamericanos De Nutricion 医学-营养学

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Archivos Latinoamericanos de Nutrición (ALAN) is the official publication of the Sociedad Latinoamericana de Nutición (SLAN), for the dissemination of knowledge in the fields of food and nutrition, principally throughout the American Hemisphere. Articles in Spanish, English, Portuguese and French are accepted, both from the Society members and from nonmembers, in the following categories: 1. General articles (critical scientific reviews); 2. Research articles (originals); 3. Papers in applied nutrition (analytical results from intervention programs and discussion of reconmendations of practical application), and 4. Letters to Editor (short comments of general interest or about scientific facts and results previously published in Archives).