An extended analysis of cardiovascular benefits of indoor air filtration intervention among elderly: a randomized crossover trial (Beijing indoor air purifier study, BIAPSY)

Global health journal (Amsterdam, Netherlands) Pub Date : 2022-03-01 DOI:10.1016/j.glohj.2022.01.001

Jie Chen , Tong Wang , Hongbing Xu , Yutong Zhu , Yipeng Du , Beibei Liu , Qian Zhao , Yi Zhang , Lingyan Liu , Ningman Yuan , Jiakun Fang , Yunfei Xie , Shuo Liu , Rongshan Wu , Danqing Shao , Xiaoming Song , Bei He , Bert Brunekreef , Wei Huang

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引用次数: 2

Abstract

Objective

Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter (PM) remains limited. We aimed to assess improvements in surrogate markers of cardiovascular injury in vulnerable populations at risks by using indoor air filtration units.

Methods

We conducted a randomized crossover trial for 2 separate 2-week air filtration interventions in 20 households of patients with stable chronic obstructive pulmonary disease and their partners in the winter of 2013, with concurrent measurements of indoor PM. The changes in biomarkers indicative of cardiac injury, atherosclerosis progression and systemic inflammation following intervention were evaluated using linear mixed-effect models.

Results

In the analysis, average levels of indoor PM with aerodynamic diameters < 2.5 µm (PM_2.5) decreased significantly by 59.2% (from 59.6 to 24.3 µg/m³, P < 0.001) during the active air filtration. The reduction was accompanied by improvements in levels of high-sensitivity cardiac troponin I by −84.6% (95% confidence interval [CI]: −90.7 to −78.6), growth differentiation factor-15 by −48.1% (95% CI: −31.2 to −25.6), osteoprotegerin by −65.4% (95% CI: −56.5 to −18.7), interleukin-4 by −46.6% (95% CI: −62.3 to −31.0) and myeloperoxidase by −60.3% (95% CI: −83.7 to −3.0), respectively.

Conclusion

Indoor air filtration intervention may provide potential cardiovascular benefits in vulnerable populations at risks.

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老年人室内空气过滤干预对心血管益处的扩展分析:一项随机交叉试验(北京室内空气净化器研究，BIAPSY)

对暴露于高水平颗粒物(PM)的老年人进行个人水平干预的潜在心血管益处的证据仍然有限。我们的目的是评估使用室内空气过滤装置对高危人群心血管损伤替代标志物的改善。方法2013年冬季对20户稳定型慢性阻塞性肺疾病患者及其伴侣进行2周空气过滤干预的随机交叉试验，同时测量室内PM。采用线性混合效应模型评估干预后指示心脏损伤、动脉粥样硬化进展和全身性炎症的生物标志物的变化。结果分析中，室内PM随空气动力学直径的平均值为;2.5µm (PM2.5)显著下降59.2%(从59.6µg/m3降至24.3µg/m3, P <0.001)，在主动空气过滤期间。与此同时，高敏心肌肌钙蛋白I水平提高了- 84.6%(95%置信区间[CI]: - 90.7至- 78.6)，生长分化因子-15水平提高了- 48.1% (95% CI: - 31.2至- 25.6)，骨保护素水平提高了- 65.4% (95% CI: - 56.5至- 18.7)，白细胞介素-4水平提高了- 46.6% (95% CI: - 62.3至- 31.0)，髓过氧化物酶水平提高了- 60.3% (95% CI: - 83.7至- 3.0)。结论室内空气过滤干预可能对高危人群的心血管疾病有潜在的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global health journal (Amsterdam, Netherlands) Public Health and Health Policy

CiteScore

5.00

自引率

0.00%

发文量