Synthesis and characteristics of BaYF5:Yb3+, Er3+@BaYF5 nanoparticles as a new near-infrared fluorescence bioimaging probe

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-10-01 DOI:10.1117/1.JNP.16.046009

Liqing Yang, X. Yang, F. Gao, Q. Fan

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引用次数: 0

Abstract

Abstract. Fluorescent bioimaging technology has been widely used in clinic because of its high sensitivity, quick feedback, and no radiation. Among them, NIR-II imaging has lower absorption, tissue scattering, self-fluorescence, and higher signal-to-noise ratio. As a precursor of nanoprobe, BaYF5 is an excellent material due to its low phonon energy, which makes it easy to achieve rare earth ion energy level transition and obtain strong upconversion luminescence. A near-infrared II (NIR-II) rare earth fluoride nanoparticle (NP) BaYF5 : Yb3 + , Er3 + @ BaYF5 has been constructed. The luminescence principle of the material was deeply analyzed, and the influence of different doping ion ratio on fluorescence intensity was explored. Finally, the optimal doping ratio for this matrix material was obtained. In addition, according to the surface properties of the materials, the water solubility and biocompatibility of the NPs were significantly improved by the modification. Our work also systematically tested and analyzed the cytotoxicity, hematotoxicity, and tissue toxicity of the NPs and finally realized the high-resolution fluorescence imaging in living mice. This NP can be used as an effective and safe NIR-II contrastive agent, which provides the possibility for the detection and monitoring of physiological activity under deep tissue in vivo.

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新型近红外荧光生物成像探针BaYF5:Yb3+，Er3+@BaYF5纳米粒子的合成与表征

摘要荧光生物成像技术具有灵敏度高、反馈快、无辐射等优点，在临床上得到了广泛的应用。其中，NIR-II成像具有较低的吸收、组织散射、自荧光和较高的信噪比。作为纳米探针的前驱体，BaYF5是一种优异的材料，因为它具有较低的声子能量，可以很容易地实现稀土离子的能级跃迁并获得强的上转换发光。近红外II（NIR-II）稀土氟化物纳米粒子（NP）BaYF5 : Yb3 + , Er3 + @ BaYF5已经建成。深入分析了该材料的发光原理，探讨了不同掺杂离子比对荧光强度的影响。最后，得到了该基体材料的最佳掺杂率。此外，根据材料的表面性质，改性显著提高了纳米颗粒的水溶性和生物相容性。我们的工作还系统地测试和分析了NPs的细胞毒性、血液毒性和组织毒性，最终实现了活体小鼠的高分辨率荧光成像。该NP可作为一种有效、安全的NIR-II对比剂，为体内深层组织下生理活性的检测和监测提供了可能。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.