Impact of Quality of Life on Prognosis of Metastatic Non-Small Cell Lung Cancer: Is It Correlated to the Chemotherapy Regimen Used?

B. Nidhal, Habouria Chaima, M. Hana, Maamar Malak, Bachouch Imen, Chermiti Fatma, Fenniche Soraya
{"title":"Impact of Quality of Life on Prognosis of Metastatic Non-Small Cell Lung Cancer: Is It Correlated to the Chemotherapy Regimen Used?","authors":"B. Nidhal, Habouria Chaima, M. Hana, Maamar Malak, Bachouch Imen, Chermiti Fatma, Fenniche Soraya","doi":"10.23937/2643-4563/1710046","DOIUrl":null,"url":null,"abstract":"Introduction: Interactions between cancer genesis, sleep quality and patient’s humor engage complex pathophysiological pathways. However, the outcome of various indicators of quality of life (Qol) after chemotherapy in non small cells lung cancer (NSCLC) and also their prognostic impact remain understudied. The objective of this study was to analyze the Qol, sleep quality and anxio-depressive disorder in advanced NSCLC patients put on chemotherapy. We aimed also to demonstrate the correlation between the Qol and overall survival (OS) of the cohort. Methods: In this monocentric prospective study, we included all patients with metastatic NSCLC, put on chemotherapy regimen from January to December 2018. We assessed the Qol, the sleep quality and disturbances of humor through dedicated questionnaires in Arabic Tunisian dialectal version. Concerning the outcome, the study mentioned the response to chemotherapy and the overall survival. The point date was on December 31st 2019. Results: Seventy one male patients were included. Their mean age was 62.17 years. Adenocarcinoma was the most frequent histologic type (58%) and then was squamous cell carcinoma (25%). When analyzing QLQ-C30, we found a significant correlation between the global Qol coefficient and the coefficient of performances, an inversely proportional correlation with the coefficient of symptoms. Analysis of PSQI score had shown a poor sleep quality in 55% of patients after chemotherapy. A depressive humor was detected in 21 patients (30%) and an anxious humor in 24 patients (34%). Twenty six patients (37%) had a tumor regression after 1st line of chemotherapy. Mean OS was 317 days (IC = 95% [292-377], margin of error of 20 days) with extremes from 1.6 months to 21 months. One year survival rate was 44%. Statistical analysis had shown a closely comparable OS in our patients, whatever was the chemotherapy regimen. OS was correlated to Performance Status, response to chemotherapy, good sleep quality and high levels of performance dimensions. Multivariate analysis found poor sleep quality and tumor progression after chemotherapy as independent predictive factors of mortality. Conclusions: Considering our results, we highlight the important decline of Qol in NSCLC patients, affecting several dimensions, whatever was the molecules of chemotherapy used. This decline would be predictive of a poor prognosis.","PeriodicalId":93572,"journal":{"name":"International journal of oncology research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of oncology research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23937/2643-4563/1710046","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Interactions between cancer genesis, sleep quality and patient’s humor engage complex pathophysiological pathways. However, the outcome of various indicators of quality of life (Qol) after chemotherapy in non small cells lung cancer (NSCLC) and also their prognostic impact remain understudied. The objective of this study was to analyze the Qol, sleep quality and anxio-depressive disorder in advanced NSCLC patients put on chemotherapy. We aimed also to demonstrate the correlation between the Qol and overall survival (OS) of the cohort. Methods: In this monocentric prospective study, we included all patients with metastatic NSCLC, put on chemotherapy regimen from January to December 2018. We assessed the Qol, the sleep quality and disturbances of humor through dedicated questionnaires in Arabic Tunisian dialectal version. Concerning the outcome, the study mentioned the response to chemotherapy and the overall survival. The point date was on December 31st 2019. Results: Seventy one male patients were included. Their mean age was 62.17 years. Adenocarcinoma was the most frequent histologic type (58%) and then was squamous cell carcinoma (25%). When analyzing QLQ-C30, we found a significant correlation between the global Qol coefficient and the coefficient of performances, an inversely proportional correlation with the coefficient of symptoms. Analysis of PSQI score had shown a poor sleep quality in 55% of patients after chemotherapy. A depressive humor was detected in 21 patients (30%) and an anxious humor in 24 patients (34%). Twenty six patients (37%) had a tumor regression after 1st line of chemotherapy. Mean OS was 317 days (IC = 95% [292-377], margin of error of 20 days) with extremes from 1.6 months to 21 months. One year survival rate was 44%. Statistical analysis had shown a closely comparable OS in our patients, whatever was the chemotherapy regimen. OS was correlated to Performance Status, response to chemotherapy, good sleep quality and high levels of performance dimensions. Multivariate analysis found poor sleep quality and tumor progression after chemotherapy as independent predictive factors of mortality. Conclusions: Considering our results, we highlight the important decline of Qol in NSCLC patients, affecting several dimensions, whatever was the molecules of chemotherapy used. This decline would be predictive of a poor prognosis.
生活质量对转移性非小细胞肺癌癌症预后的影响:与化疗方案有关吗?
导读:癌症发生、睡眠质量和患者情绪之间的相互作用涉及复杂的病理生理途径。然而,非小细胞肺癌(NSCLC)化疗后生活质量(Qol)的各种指标的结果及其对预后的影响仍未得到充分研究。本研究的目的是分析晚期NSCLC化疗患者的生活质量、睡眠质量和焦虑抑郁障碍。我们还旨在证明队列的生活质量和总生存期(OS)之间的相关性。方法:在这项单中心前瞻性研究中,我们纳入了2018年1月至12月接受化疗方案的所有转移性非小细胞肺癌患者。我们通过阿拉伯语突尼斯方言版本的专用问卷评估生活质量,睡眠质量和幽默干扰。关于结局,研究提到了对化疗的反应和总生存期。关键日期是2019年12月31日。结果:纳入男性患者71例。他们的平均年龄为62.17岁。腺癌是最常见的组织学类型(58%),其次是鳞状细胞癌(25%)。在分析QLQ-C30时,我们发现总体生活质量系数与绩效系数之间存在显著相关性,与症状系数呈反比相关。PSQI评分分析显示,化疗后55%的患者睡眠质量较差。抑郁幽默21例(30%),焦虑幽默24例(34%)。26例(37%)患者在一线化疗后肿瘤消退。平均OS为317天(IC = 95%[292-377],误差范围为20天),极值为1.6个月至21个月。1年生存率为44%。统计分析显示,无论化疗方案是什么,我们的患者的OS都非常相似。OS与表现状态、化疗反应、良好睡眠质量和高水平表现维度相关。多变量分析发现,化疗后睡眠质量差和肿瘤进展是死亡率的独立预测因素。结论:考虑到我们的结果,我们强调了NSCLC患者生活质量的重要下降,影响了几个维度,无论使用的是哪种化疗分子。这种下降可能预示着预后不良。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信