Asthma: Cells involved in the pathophysiology of asthma

Abstract

Asthma is a complex chronic inflammatory disease of the bronchioles characterized by airway hyperresponsiveness, bronchial hyperresponsiveness, and airway obstruction. Asthma is classified into various types. The epidemiological studies say that there are approximately 310 million people affected. The asthma prevalence is increasing considerably among developing and developed nations. Many of the patients remain undiagnosed because of the lack of healthcare facilities. Asthma is a complex disease that involves several cells (T-lymphocytes, B-lymphocytes, mast cells, eosinophils, dendritic cells, macrophages, chemokines, cytokines, histamines) that when activated can trigger the pathogenesis of asthma. The pathogenesis of each cell varies from the other. It also varies with age, gender, and exposure type.