Mechanisms of coherent re-arrangement for long-lived spin order

Q3 Physics and Astronomy
F. Teleanu, P. Vasos
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引用次数: 1

Abstract

Abstract. Long-lived spin order-based approaches for magnetic resonance rely on the transition between two magnetic environments of different symmetry, one governed by the magnetic field of the spectrometer and the other where this strong magnetic field is inconsequential. Research on the excitation of magnetic-symmetry transitions in nuclear spins is a scientific field that debuted in Southampton in the years 2000. We advanced in this field carrying the baggage of pre-established directions in NMR spectroscopy. We propose to reveal in this text the part of discoveries that may have been obscured by our choice to only look at them through the experience of such pre-established directions, at the time. Focussing on potential applications, we may have insufficiently emphasised in the manuscripts the methodological developments that necessitated most scientific effort. Such methods developments foster most of the progress in NMR. Thus, we present the contributed mechanisms of translation between the symmetric and non-symmetric environments with respect to the main magnetic field B0, free of any utilitarian perspective. The concept of zero-quantum rotations in the starting blocks of long-lived state populations, magnetisation transfers between hyperpolarised heteronuclei and protons, and selective inversion for long-lived coherences are discussed, as well as hybrid 2D methods based on both insensitive nuclei excitation (“INEPT”) and long-lived spin order. We can see at this point that these magnetic wheels will take a longer time than we initially thought to set in motion new applications in studies of slow diffusion, angiography, or large-protein structure. However, these pulse sequences seed subsequent magnetic mechanisms that are sure to contribute to applications. For instance, some of the introduced coherence rotations were combined with classical pulse blocks to obtain 2D correlations between protons and heteronuclei. We hope the pulse sequence building blocks discussed herein open further perspectives for magnetic resonance experiments with long-lived spin order.
长寿命自旋秩序的相干重排机制
摘要长期存在的基于自旋序的磁共振方法依赖于两种不同对称的磁环境之间的跃迁,其中一种由光谱仪的磁场控制,而另一种强磁场则无关紧要。核自旋磁对称跃迁的激发研究是2000年在南安普顿首次出现的一个科学领域。我们带着核磁共振波谱学预先确定的方向在这一领域取得进展。我们打算在这篇文章中揭示部分发现,这些发现可能被我们的选择所掩盖,即只通过这些预先确定的方向的经验来看待它们,当时。关注潜在的应用,我们可能在手稿中没有充分强调需要大多数科学努力的方法发展。这些方法的发展促进了核磁共振的大部分进展。因此,我们提出了关于主磁场B0的对称和非对称环境之间的翻译机制,没有任何功利主义的观点。讨论了长寿命态居群起始块中的零量子旋转概念、超极化异核和质子之间的磁化转移以及长寿命相干的选择性反转,以及基于不敏感核激发(“INEPT”)和长寿命自旋顺序的混合二维方法。在这一点上,我们可以看到,这些磁轮将花费比我们最初想象的更长的时间来启动在慢扩散,血管造影或大蛋白质结构研究中的新应用。然而,这些脉冲序列种子随后的磁机制,肯定有助于应用。例如,一些引入的相干旋转与经典脉冲块相结合,以获得质子和异核之间的二维相关性。我们希望本文讨论的脉冲序列构建块为具有长寿命自旋序的磁共振实验开辟了进一步的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
0.00%
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审稿时长
14 weeks
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