Sargassum horneri Extract Alleviates Testosterone-Induced Benign Prostatic Hyperplasia In vitro and In vivo

IF 1.3 4区农林科学 Q4 FOOD SCIENCE & TECHNOLOGY

Journal of Aquatic Food Product Technology Pub Date : 2022-10-20 DOI:10.1080/10498850.2022.2132126

Yae-Ji Kim, Kyung-Hyun Kim, Hyun-Yong Kim, S. Kang, Geum-Lan Hong, Hui-Ju Lee, S. Lim, Ju-Young Jung

{"title":"Sargassum horneri Extract Alleviates Testosterone-Induced Benign Prostatic Hyperplasia In vitro and In vivo","authors":"Yae-Ji Kim, Kyung-Hyun Kim, Hyun-Yong Kim, S. Kang, Geum-Lan Hong, Hui-Ju Lee, S. Lim, Ju-Young Jung","doi":"10.1080/10498850.2022.2132126","DOIUrl":null,"url":null,"abstract":"ABSTRACT Sargassum horneri (Turner) C. Agardh (S. horneri) is brown algae that grows on the broad ranges in the Western Pacific, spanning from Northern Japan to the Philippines. S. horneri has been used as local food and traditional medicine for thousands of years in East Asia. However, little is known about its effects on benign prostatic hyperplasia (BPH). In this study, we investigated the effects of S. horneri extract in testosterone propionate (TP)-induced BPH in vitro and in vivo. Treatment with S. horneri extract significantly decreased the expression of androgen receptor, prostate-specific antigen, and 5α-reductase type 2 in TP-induced BPH in vitro and in vivo. Additionally, S. horneri extract treatment significantly increased the Bax/Bcl-2 ratio, indicating increased cell apoptosis. Therefore, these results collectively show that S. horneri extract can alleviate TP-induced BPH and the possibility of using S. horneri extract as a therapeutic agent for the treatment of BPH.","PeriodicalId":15091,"journal":{"name":"Journal of Aquatic Food Product Technology","volume":"31 1","pages":"1049 - 1060"},"PeriodicalIF":1.3000,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aquatic Food Product Technology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/10498850.2022.2132126","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

ABSTRACT Sargassum horneri (Turner) C. Agardh (S. horneri) is brown algae that grows on the broad ranges in the Western Pacific, spanning from Northern Japan to the Philippines. S. horneri has been used as local food and traditional medicine for thousands of years in East Asia. However, little is known about its effects on benign prostatic hyperplasia (BPH). In this study, we investigated the effects of S. horneri extract in testosterone propionate (TP)-induced BPH in vitro and in vivo. Treatment with S. horneri extract significantly decreased the expression of androgen receptor, prostate-specific antigen, and 5α-reductase type 2 in TP-induced BPH in vitro and in vivo. Additionally, S. horneri extract treatment significantly increased the Bax/Bcl-2 ratio, indicating increased cell apoptosis. Therefore, these results collectively show that S. horneri extract can alleviate TP-induced BPH and the possibility of using S. horneri extract as a therapeutic agent for the treatment of BPH.

查看原文本刊更多论文

马尾藻提取物在体外和体内减轻睾丸激素诱导的良性前列腺增生

马尾藻(Sargassum horneri)是一种生长在西太平洋广阔海域的褐藻，从日本北部一直延伸到菲律宾。在东亚，牛角菌作为当地食物和传统药物已有数千年的历史。然而，它对良性前列腺增生(BPH)的作用知之甚少。在本研究中，我们在体内和体外研究了牛角草提取物对丙酸睾酮(TP)诱导的前列腺增生的影响。在体外和体内实验中，霍氏葡萄球菌提取物显著降低了tp诱导BPH中雄激素受体、前列腺特异性抗原和5α-还原酶2型的表达。此外，金针菇提取物显著提高了Bax/Bcl-2比值，表明细胞凋亡增加。因此，这些结果共同表明，霍氏棘球菌提取物可以减轻tp诱导的BPH，并有可能将霍氏棘球菌提取物作为治疗BPH的治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Aquatic Food Product Technology 农林科学-食品科技

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

7 months

期刊介绍： The Journal of Aquatic Food Product Technology publishes research papers, short communications, and review articles concerning the application of science and technology and biotechnology to all aspects of research, innovation, production, and distribution of food products originating from the marine and freshwater bodies of the world. The journal features articles on various aspects of basic and applied science in topics related to: -harvesting and handling practices- processing with traditional and new technologies- refrigeration and freezing- packaging and storage- safety and traceability- byproduct utilization- consumer attitudes toward aquatic food. The Journal also covers basic studies of aquatic products as related to food chemistry, microbiology, and engineering, such as all flora and fauna from aquatic environs, including seaweeds and underutilized species used directly for human consumption or alternative uses. Special features in the journal include guest editorials by specialists in their fields and book reviews covering a wide range of topics.