Association between Smoking and Overall and Specific Mortality in Patients with Bladder Cancer: A Population-based Study.

IF 1 4区医学 Q4 ONCOLOGY

Bladder Cancer Pub Date : 2022-06-03 eCollection Date: 2022-01-01 DOI:10.3233/BLC-211583

Chung-Han Ho, Wen-Hsin Tseng, Steven K Huang, Chien-Liang Liu, Yu-Cih Wu, Allen W Chiu, Khaa Hoo Ong

{"title":"Association between Smoking and Overall and Specific Mortality in Patients with Bladder Cancer: A Population-based Study.","authors":"Chung-Han Ho, Wen-Hsin Tseng, Steven K Huang, Chien-Liang Liu, Yu-Cih Wu, Allen W Chiu, Khaa Hoo Ong","doi":"10.3233/BLC-211583","DOIUrl":null,"url":null,"abstract":"Background: The role of smoking in the prognosis of bladder cancer may significantly impact clinical management. It is also a considerable burden to Taiwan's economy and health of its citizens.Objective: To search Taiwan's National Health Insurance Research Database to determine whether smoking affected overall and cancer-specific mortality of patients with bladder cancer.Methods: We collected data on basic information, tumor stage, and comorbidities. Each smoking case was propensity score-matched by age, sex, and diagnosis year to one control individual among bladder cancer patients. The study comprised a never-smoke and an ever-smoke group, with each group including 4,728 patients after matching. We evaluated the association between smoking and mortalities in patients with bladder cancer. Cox proportional regression modeling was used to estimate hazard ratios (HRs) of overall and cancer-specific mortality rates. Stratified analysis was also performed to estimate risk ratios of overall and cancer-specific mortalities in bladder cancer patients with and without a history of smoking history among different subgroups.Results: The overall and specific mortality ratio of patients who were ever smokers were 1.15-fold and 1.16-fold, respectively, compared with those of never smokers (overall: 95% confidence interval [CI], 1.06-1.26, P = 0.0014; specific: 95% CI, 1.03-1. 03, P = 0.0176). Patients with bladder cancer who smoked and had significantly higher overall and specific mortality rates were those with Charlson Comorbidity Index (CCI)≥3 (overall: P = 0.0119; specific: P = 0.0092), diabetes mellitus (DM; overall: P = 0.0046; specific: P = 0.0419), and non-muscle-invasive bladder cancer (NMIBC; overall: P = 0.0038; specific: P = 0.0014).Conclusions: Overall and specific mortality rates were significantly higher in the ever-smoke group than in the never-smoke group. The ever-smoke group with male sex, CCI≥3, DM, and NMIBC had increased risks for overall and specific mortality.","PeriodicalId":54217,"journal":{"name":"Bladder Cancer","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181781/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bladder Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3233/BLC-211583","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The role of smoking in the prognosis of bladder cancer may significantly impact clinical management. It is also a considerable burden to Taiwan's economy and health of its citizens.

Objective: To search Taiwan's National Health Insurance Research Database to determine whether smoking affected overall and cancer-specific mortality of patients with bladder cancer.

Methods: We collected data on basic information, tumor stage, and comorbidities. Each smoking case was propensity score-matched by age, sex, and diagnosis year to one control individual among bladder cancer patients. The study comprised a never-smoke and an ever-smoke group, with each group including 4,728 patients after matching. We evaluated the association between smoking and mortalities in patients with bladder cancer. Cox proportional regression modeling was used to estimate hazard ratios (HRs) of overall and cancer-specific mortality rates. Stratified analysis was also performed to estimate risk ratios of overall and cancer-specific mortalities in bladder cancer patients with and without a history of smoking history among different subgroups.

Results: The overall and specific mortality ratio of patients who were ever smokers were 1.15-fold and 1.16-fold, respectively, compared with those of never smokers (overall: 95% confidence interval [CI], 1.06-1.26, P = 0.0014; specific: 95% CI, 1.03-1. 03, P = 0.0176). Patients with bladder cancer who smoked and had significantly higher overall and specific mortality rates were those with Charlson Comorbidity Index (CCI)≥3 (overall: P = 0.0119; specific: P = 0.0092), diabetes mellitus (DM; overall: P = 0.0046; specific: P = 0.0419), and non-muscle-invasive bladder cancer (NMIBC; overall: P = 0.0038; specific: P = 0.0014).

Conclusions: Overall and specific mortality rates were significantly higher in the ever-smoke group than in the never-smoke group. The ever-smoke group with male sex, CCI≥3, DM, and NMIBC had increased risks for overall and specific mortality.

查看原文本刊更多论文

吸烟与膀胱癌患者总体和特定死亡率之间的关系:一项基于人群的研究

背景:吸烟在膀胱癌预后中的作用可能会显著影响临床治疗。这对台湾的经济和公民的健康也是相当大的负担。目的:检索台湾全民健康保险研究数据库，以确定吸烟是否影响膀胱癌患者的总体死亡率和癌症特异性死亡率。方法:我们收集基本信息、肿瘤分期和合并症的资料。在膀胱癌患者中，每个吸烟病例按年龄、性别和诊断年份与一个对照个体进行倾向评分匹配。该研究分为从不吸烟组和经常吸烟组，每组匹配后包括4,728名患者。我们评估了膀胱癌患者吸烟与死亡率之间的关系。Cox比例回归模型用于估计总体死亡率和癌症特异性死亡率的风险比(hr)。还进行了分层分析，以估计不同亚组中有和没有吸烟史的膀胱癌患者的总体死亡率和癌症特异性死亡率的风险比。结果:与不吸烟者相比，曾经吸烟患者的总死亡率和特定死亡率分别为1.15倍和1.16倍(总体:95%可信区间[CI]， 1.06-1.26, P = 0.0014;特异性:95% CI, 1.03-1。03, p = 0.0176)。吸烟的膀胱癌患者总体死亡率和特定死亡率均显著高于Charlson合并症指数(CCI)≥3的患者(总体:P = 0.0119;特异性:P = 0.0092)，糖尿病(DM;总体:P = 0.0046;特异性:P = 0.0419)，非肌肉浸润性膀胱癌(NMIBC;总体:P = 0.0038;特异性:P = 0.0014)。结论:吸烟组的总死亡率和特定死亡率显著高于不吸烟组。经常吸烟的男性、CCI≥3、糖尿病和NMIBC组的总死亡率和特异性死亡率风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bladder Cancer Medicine-Urology

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： Bladder Cancer is an international multidisciplinary journal to facilitate progress in understanding the epidemiology/etiology, genetics, molecular correlates, pathogenesis, pharmacology, ethics, patient advocacy and survivorship, diagnosis and treatment of tumors of the bladder and upper urinary tract. The journal publishes research reports, reviews, short communications, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that expedites our fundamental understanding and improves treatment of tumors of the bladder and upper urinary tract.