Radiological Abnormalities and Asymptomatic Bacteriuria in Patients with Sickle Cell Disease

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

West Indian Medical Journal Pub Date : 2017-10-26 DOI:10.7727/WIMJ.2017.203

B. Morrison, D. Cornwall, Wendy Madden, P. Johnson, M. Didier, M. Reid

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引用次数: 0

Abstract

Objective: The prevalence of asymptomatic bacteriuria (ASB) in sickle cell disease (SCD) in Jamaica is 5.3%. This study sought to determine the association between ASB and anatomical urological abnormalities and symptomatic urinary tract infections (UTIs). Methods: A matched case-controlled study of 11 patients with a history of ASB from the Jamaican Sickle Cell Cohort and 11 controls who did not have a history of ASB or recurrent UTIs but who had SCD was conducted. Midstream urine collected aseptically was obtained for urinalysis and culture and sensitivity analysis. Serum creatinine was measured. Voiding cystourethrogram (VCUG) and kidney-ureter-bladder ultrasound were done. History of UTIs was recorded in all cases. Results: The mean ± sd age of the group (cases and controls) was 34.2 ± 7.2 years. All VCUGs were normal. There was no difference in mean cortical thickness or renal scarring between cases and controls. All serum creatinine values were normal: cases (mean ± sd: 55.9 ± 15.3; min-max: 32–90 μmol/L) and controls (mean ± sd: 59.6 ± 18.5; min-max: 41–95 μmol/L). There was no difference in symptomatic UTIs between cases and controls. Conclusion: There was no association between anatomical urinary tract abnormalities and ASB in patients with SCD. Asymptomatic bacteriuria in SCD was not associated with increased numbers of symptomatic UTIs.

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镰状细胞病患者的放射学异常和无症状菌尿

目的：牙买加镰状细胞病（SCD）中无症状菌尿症（ASB）的患病率为5.3%。本研究旨在确定ASB与解剖泌尿系统异常和症状性尿路感染（UTIs）之间的关系。方法：对来自牙买加镰状细胞队列的11名有ASB病史的患者和11名没有ASB或复发性尿路感染史但患有SCD的对照组进行匹配的病例对照研究。无菌收集的中游尿液用于尿液分析、培养和敏感性分析。测量血清肌酸酐。造瘘膀胱尿道造影（VCUG）和肾输尿管膀胱超声检查。所有病例均有尿路感染史。结果：本组（病例和对照组）的平均±sd年龄为34.2±7.2岁。所有VCUGs均正常。病例和对照组的平均皮质厚度或肾瘢痕形成没有差异。所有血清肌酐值均正常：病例（平均值±标准差：55.9±15.3；最小-最大值：32-90μmol/L）和对照组（平均值？标准差：59.6±18.5；最小-最高值：41-95μmol/L）。病例和对照组之间的症状性尿路感染没有差异。结论：SCD患者尿路解剖异常与ASB无相关性。SCD的无症状菌尿与症状性尿路感染数量增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

West Indian Medical Journal 医学-医学：内科

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal is international in scope, with author and editorial contributions from across the globe. The focus is on clinical and epidemiological aspects of tropical and infectious diseases, new and re-emerging infections, chronic non-communicable diseases, and medical conditions prevalent in the Latin America-Caribbean region, and of significance to global health, especially in developing countries. The Journal covers all medical disciplines, as well as basic and translational research elucidating the pathophysiologic basis of diseases or focussing on new therapeutic approaches, and publishes original scientific research, reviews, case reports, brief communications, letters, commentaries and medical images. The Journal publishes four to six issues and four supplements annually. English is the language of publication but Abstracts are also duplicated in Spanish. Most of the articles are submitted at the authors’ initiative, but some are solicited by the Editor-in-Chief. Unless expressly stated, the Editorial Board does not accept responsibility for authors’ opinions. All papers on submission are reviewed by a subcommittee. Those deemed worthy for review are sent to two or three reviewers (one of the three might be a statistician if necessary). The returned papers with reviewer comments are reviewed by the Editor-in-Chief. Papers may be rejected, accepted or sent back to authors for revision. Resubmitted papers from authors are reviewed by the Editor-in-Chief and may be sent back to reviewers or a final decision made by Editor-in-Chief. The decision of the Editorial Board is final with regards to rejected articles. Rejected articles will not be returned to the authors. The editorial subcommittee has the right to return sub-standard manuscripts to the authors, rather than passing them on to the reviewers. This implies outright rejection of the manuscript.